| Role of paraventricular nucleus in exercise training-induced autonomic modulation in conscious rats. | |
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MedLine Citation:
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PMID: 19297253 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The paraventricular nucleus (PVN) of the hypothalamus is an important site for autonomic regulation, where gamma-aminobutyric acid (GABA) system plays an important role. The central mechanisms underlying modulatory effects of exercise training have yet to be characterized. Our objective was to analyze the effects on the autonomic modulation and hemodynamic parameters after bicuculline or muscimol injections into the PVN of sedentary (control, C) and previously submitted to swimming training (ST) rats. After ST protocol, adult male Wistar rats, instrumented with guide cannulas to PVN and femoral artery and vein catheters were submitted to mean arterial pressure (MAP) recording. The exercise training reduced the LF oscillations in normalized units and increased the HF oscillations in absolute and normalized units. Compared with the C group, muscimol microinjections in the ST group promoted a higher decrease in MAP (C=-14+/-1 vs. ST=-28+/-4 mm Hg). Spectral analysis of HR (pulse interval) showed that the muscimol microinjections also reduced LF and HF oscillations in absolute units in both groups. Bicuculline microinjections increased the systolic arterial pressure (C=155+/-5, ST=164+/-5 mm Hg) in ST compared with the C group. Bicuculline injections also increased the LF oscillations of HR in absolute units in C and ST groups. Meanwhile, in normalized units only the ST group showed an increase in the LF oscillations. Our data showed that PVN has an important role in autonomic modulation after exercise training. |
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Authors:
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Samantha Bagolan de Abreu; Adriane Lenhard; Aida Mehanna; Hugo Celso Dutra de Souza; Fernando Morgan de Aguiar Correa; Eileen M Hasser; Marli Cardoso Martins-Pinge |
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Publication Detail:
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Type: Journal Article Date: 2009-03-18 |
Journal Detail:
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Title: Autonomic neuroscience : basic & clinical Volume: 148 ISSN: 1872-7484 ISO Abbreviation: Auton Neurosci Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-08 Completed Date: 2009-07-23 Revised Date: 2009-08-12 |
Medline Journal Info:
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Nlm Unique ID: 100909359 Medline TA: Auton Neurosci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 28-35 Citation Subset: IM |
Affiliation:
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Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / physiology Bicuculline / pharmacology Blood Pressure / drug effects, physiology* GABA Agonists / pharmacology GABA Antagonists / pharmacology Heart Rate / drug effects, physiology* Male Muscimol / pharmacology Paraventricular Hypothalamic Nucleus / drug effects, physiology* Physical Conditioning, Animal / physiology* Rats Rats, Wistar Spectrum Analysis Swimming / physiology Wakefulness |
| Chemical | |
Reg. No./Substance:
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0/GABA Agonists; 0/GABA Antagonists; 2763-96-4/Muscimol; 485-49-4/Bicuculline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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