Document Detail


Role of paraventricular nucleus in exercise training-induced autonomic modulation in conscious rats.
MedLine Citation:
PMID:  19297253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The paraventricular nucleus (PVN) of the hypothalamus is an important site for autonomic regulation, where gamma-aminobutyric acid (GABA) system plays an important role. The central mechanisms underlying modulatory effects of exercise training have yet to be characterized. Our objective was to analyze the effects on the autonomic modulation and hemodynamic parameters after bicuculline or muscimol injections into the PVN of sedentary (control, C) and previously submitted to swimming training (ST) rats. After ST protocol, adult male Wistar rats, instrumented with guide cannulas to PVN and femoral artery and vein catheters were submitted to mean arterial pressure (MAP) recording. The exercise training reduced the LF oscillations in normalized units and increased the HF oscillations in absolute and normalized units. Compared with the C group, muscimol microinjections in the ST group promoted a higher decrease in MAP (C=-14+/-1 vs. ST=-28+/-4 mm Hg). Spectral analysis of HR (pulse interval) showed that the muscimol microinjections also reduced LF and HF oscillations in absolute units in both groups. Bicuculline microinjections increased the systolic arterial pressure (C=155+/-5, ST=164+/-5 mm Hg) in ST compared with the C group. Bicuculline injections also increased the LF oscillations of HR in absolute units in C and ST groups. Meanwhile, in normalized units only the ST group showed an increase in the LF oscillations. Our data showed that PVN has an important role in autonomic modulation after exercise training.
Authors:
Samantha Bagolan de Abreu; Adriane Lenhard; Aida Mehanna; Hugo Celso Dutra de Souza; Fernando Morgan de Aguiar Correa; Eileen M Hasser; Marli Cardoso Martins-Pinge
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Publication Detail:
Type:  Journal Article     Date:  2009-03-18
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  148     ISSN:  1872-7484     ISO Abbreviation:  Auton Neurosci     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-08     Completed Date:  2009-07-23     Revised Date:  2009-08-12    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  28-35     Citation Subset:  IM    
Affiliation:
Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / physiology
Bicuculline / pharmacology
Blood Pressure / drug effects,  physiology*
GABA Agonists / pharmacology
GABA Antagonists / pharmacology
Heart Rate / drug effects,  physiology*
Male
Muscimol / pharmacology
Paraventricular Hypothalamic Nucleus / drug effects,  physiology*
Physical Conditioning, Animal / physiology*
Rats
Rats, Wistar
Spectrum Analysis
Swimming / physiology
Wakefulness
Chemical
Reg. No./Substance:
0/GABA Agonists; 0/GABA Antagonists; 2763-96-4/Muscimol; 485-49-4/Bicuculline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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