| Role of paraventricular and dorsomedial nuclei of the hypothalamus and central nucleus of the amygdala on muscimol-induced cardiovascular responses. | |
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MedLine Citation:
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PMID: 9342594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gamma-aminobutyric acid (GABA) plays an important role in the central control of cardiovascular functions. Previous evidence indicates that a tonically active GABAergic system exists in forebrain structures. The purpose of this study was to examine the role of the unilateral lesion of the central nucleus of amygdala, paraventricular or dorsomedial nuclei of the hypothalamus on muscimol-induced cardiovascular responses. Electrolytic ablation of nuclei was made by a monopolar isolated electrode under a stereotaxic instrument, 3-5 days before the experiments. Effects of intracerebroventricular injections of muscimol were investigated in intact, lesioned and sham-lesioned rats. On the day of the experiments, blood pressure and heart rate recordings were carried out in male Sprague-Dawley conscious rats. Muscimol produced decreases in arterial blood pressure and heart rate. The hypotensive effect of muscimol was completely inhibited in rats with dorsomedial nucleus lesions, whereas the bradycardic effect was partially prevented. The results indicate that the dorsomedial nucleus of the hypothalamus plays an important role on muscimol-induced blood pressure and heart rate responses. |
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Authors:
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Z Gören; N Aslan; K Berkman; T San; O Sule; F Onat |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Fundamental & clinical pharmacology Volume: 11 ISSN: 0767-3981 ISO Abbreviation: Fundam Clin Pharmacol Publication Date: 1997 |
Date Detail:
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Created Date: 1997-12-08 Completed Date: 1997-12-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8710411 Medline TA: Fundam Clin Pharmacol Country: FRANCE |
Other Details:
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Languages: eng Pagination: 408-15 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Medicine, Marmara University, Istanbul, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amygdala
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drug effects*,
physiology Animals Blood Pressure / physiology* GABA Agonists / pharmacology* Heart Rate / physiology* Hypothalamus / drug effects*, physiology Injections, Intraventricular Male Muscimol / pharmacology* Rats Rats, Sprague-Dawley Receptors, GABA-A / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/GABA Agonists; 0/Receptors, GABA-A; 2763-96-4/Muscimol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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