| Role of pancreatic-derived factor in type 2 diabetes: evidence from pancreatic β cells and liver. | |
| | |
MedLine Citation:
|
PMID: 22300596 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Pancreatic-derived factor (PANDER) is a cytokine-like protein that is highly expressed in pancreatic islets. In vitro, PANDER pretreatment or viral-mediated overexpression promotes apoptosis of islet β cells. Under conditions of insulin resistance, chronic hyperglycemia potently activates PANDER expression and stimulates the cosecretion of insulin and PANDER in β cells. PANDER binds to the liver cell membrane and induces insulin resistance, resulting in increased gluconeogenesis. Recently, PANDER was found to be expressed in rodent and human liver, and its expression is increased in the liver of diabetic mice and rats. Hepatic overexpression of PANDER promotes lipogenesis in the liver and induces insulin resistance in C57BL/6 mice, whereas the inactivation of hepatic PANDER markedly reduces steatosis, insulin resistance, and hyperglycemia in db/db mice. PANDER deficiency protects mice from high-fat-diet-induced hyperglycemia by decreasing gluconeogenesis in the liver. In summary, PANDER plays an important role in the progression of type 2 diabetes by negatively regulating islet β-cell function and insulin sensitivity in the liver. |
| | |
Authors:
|
Chunjiong Wang; Brant R Burkhardt; Youfei Guan; Jichun Yang |
Related Documents
:
|
19624786 - Use of therapeutic responses to glucose replacement to predict glucose patterns in diab... 15258736 - Long-term evaluation of a structured outpatient education programme for intensified ins... 14984436 - Global assessment for quality and safety of control in type 2 diabetic patients. 16454166 - A low carbohydrate diet in type 1 diabetes: clinical experience--a brief report. 1245266 - Relationship of serum glucose concentration to changes in refraction. 831106 - Decreased binding of insulin to its receptor in patients with congenital generalized li... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nutrition reviews Volume: 70 ISSN: 1753-4887 ISO Abbreviation: Nutr. Rev. Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-02-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376405 Medline TA: Nutr Rev Country: United States |
Other Details:
|
Languages: eng Pagination: 100-6 Citation Subset: IM |
Copyright Information:
|
© 2012 International Life Sciences Institute. |
Affiliation:
|
Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Science, Peking University Health Science Center, Beijing 100191, China Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of the evidence between consumption of refined grains and health outcomes.
Next Document: Anticoagulant activity of select dietary supplements.