Document Detail

Role of p53 mutations on survival after pancreatoduodenectomy for ductal adenocarcinoma of the pancreatic head.
MedLine Citation:
PMID:  11813614     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: To determine the role of p53 mutations on survival after pancreatoduodenectomy for adenocarcinoma of the pancreatic head. METHODOLOGY: Resected specimens were assessed for expression of wild-type or mutated p53. Survival of p53-negative and- positive patients was investigated, and differences noted at 0.05 level. RESULTS: Expression of wild-type p53 is associated with a significant improvement in overall survival, especially for patients without nodal metastases. CONCLUSIONS: Preoperative p53 determination could enable further patient selection for aggressive surgery.
G M Gazzaniga; F S Papadia; M Dezzana; S Cappato; M Filauro; R Bandelloni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  48     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2001 Nov-Dec
Date Detail:
Created Date:  2002-01-29     Completed Date:  2002-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1743-5     Citation Subset:  IM    
HPB Unit, First Division of General Surgery, Galliera Hospital, Genoa, Italy.
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MeSH Terms
Carcinoma, Ductal, Breast / genetics*,  mortality*,  pathology,  surgery
Genes, p53 / genetics*
Neoplasm Staging
Pancreatic Neoplasms / genetics*,  mortality*,  pathology,  surgery
Survival Analysis

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