Document Detail


Role of p53 mutations on survival after pancreatoduodenectomy for ductal adenocarcinoma of the pancreatic head.
MedLine Citation:
PMID:  11813614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: To determine the role of p53 mutations on survival after pancreatoduodenectomy for adenocarcinoma of the pancreatic head. METHODOLOGY: Resected specimens were assessed for expression of wild-type or mutated p53. Survival of p53-negative and- positive patients was investigated, and differences noted at 0.05 level. RESULTS: Expression of wild-type p53 is associated with a significant improvement in overall survival, especially for patients without nodal metastases. CONCLUSIONS: Preoperative p53 determination could enable further patient selection for aggressive surgery.
Authors:
G M Gazzaniga; F S Papadia; M Dezzana; S Cappato; M Filauro; R Bandelloni
Related Documents :
24397794 - Radical cystectomy and the implications of comorbidity.
10705094 - Prognostic significance of ki-67 (mib1), pcna and p53 in cancer of the oropharynx and o...
24862564 - Routine prophylactic central neck dissection for low risk papillary thyroid cancer is n...
8608524 - New prognostic factors in nasopharyngeal carcinoma. tumor angiogenesis and c-erbb2 expr...
20100144 - Baseline physical functioning status of metastatic colorectal cancer patients predicts ...
25302724 - Haploidentical peripheral blood stem cell infusion in combination with chemotherapy for...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  48     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2001 Nov-Dec
Date Detail:
Created Date:  2002-01-29     Completed Date:  2002-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1743-5     Citation Subset:  IM    
Affiliation:
HPB Unit, First Division of General Surgery, Galliera Hospital, Genoa, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Carcinoma, Ductal, Breast / genetics*,  mortality*,  pathology,  surgery
Female
Genes, p53 / genetics*
Humans
Male
Mutation
Neoplasm Staging
Pancreatectomy*
Pancreatic Neoplasms / genetics*,  mortality*,  pathology,  surgery
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Spontaneous regression of hepatocellular carcinoma--a case report.
Next Document:  Evaluation of hemostatic changes and blood antioxidant capacity in acute and chronic pancreatitis.