| Role of oxygen-derived free radicals in myocardial edema and ischemia in coronary microvascular embolization. | |
| | |
MedLine Citation:
|
PMID: 1860225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Oxygen-derived free radicals are thought to injure the ischemic heart during coronary microvascular embolization. METHODS AND RESULTS: To test this idea, microspheres (15 microns in diameter) were repetitively administered into the left anterior descending coronary artery to cause microvascular embolization in dogs. Myocardial contractile and metabolic dysfunctions were significantly attenuated after treatments with recombinant human superoxide dismutase, an acyl derivative of ascorbic acid (CV3611, 2-O-octadecylascorbic acid), and xanthine oxidase inhibitor (allopurinol). The free radical scavengers and inhibitor enhanced the coronary hyperemic flow response during embolization, and the total number of microspheres causing maximal embolization was increased by these drugs. When 8-phenyltheophylline was additionally administered with superoxide dismutase, these beneficial effects were abolished, indicating that coronary effects of these drugs may be due to increased release of adenosine during coronary microvascular embolization. CONCLUSIONS: We conclude that oxygen radicals worsen the ischemic injury in coronary microembolization. |
| | |
Authors:
|
M Hori; K Gotoh; M Kitakaze; K Iwai; K Iwakura; H Sato; Y Koretsune; M Inoue; A Kitabatake; T Kamada |
Related Documents
:
|
8721395 - Myocardial protection during reperfusion. 23008645 - Sildenafil (viagra) and the heart. 23154655 - Statin-mediated low-density lipoprotein lowering in chronic congestive heart failure. 23335565 - Mimicking native extracellular matrix with phytic acid-crosslinked protein nanofibers f... 22263025 - Qt dispersion as a predictor for arrhythmias in patients with acute st elevation myocar... 17319455 - A review of perindopril in the reduction of cardiovascular events. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Circulation Volume: 84 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1991 Aug |
Date Detail:
|
Created Date: 1991-08-30 Completed Date: 1991-08-30 Revised Date: 2010-03-24 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 828-40 Citation Subset: AIM; IM |
Affiliation:
|
First Department of Medicine, Osaka University Medical School, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Allopurinol
/
pharmacology Animals Ascorbic Acid / analogs & derivatives, pharmacology Body Water / metabolism Cardiomyopathies / etiology* Coronary Disease / etiology*, metabolism, pathology Dogs Edema / etiology* Embolism / etiology*, metabolism, pathology Free Radical Scavengers Free Radicals Microcirculation Microspheres Oxygen / physiology* Superoxide Dismutase / pharmacology Theophylline / analogs & derivatives, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Free Radical Scavengers; 0/Free Radicals; 315-30-0/Allopurinol; 50-81-7/Ascorbic Acid; 58-55-9/Theophylline; 7782-44-7/Oxygen; 961-45-5/8-phenyltheophylline; 98829-12-0/2-O-octadecylascorbic acid; EC 1.15.1.1/Superoxide Dismutase |
| Comments/Corrections | |
Comment In:
|
Circulation. 1991 Aug;84(2):951-4
[PMID:
1860244
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prevention of arterial reocclusion after thrombolysis with recombinant lipoprotein-associated coagul...
Next Document: Anatomy of the tricuspid annulus. Circumferential myofibers as the structural basis for atrial flutt...