Document Detail

Role for oxidative stress in the regeneration of islet beta cells?
MedLine Citation:
PMID:  14989369     Owner:  NLM     Status:  MEDLINE    
In the nonobese diabetic (NOD) mouse model of type 1 diabetes, we have found that there are increased markers of oxidative stress in islet beta cells in prediabetic animals when compared with control strains. Treatment of these mice with a superoxide dismutase (SOD) mimetic can markedly reduce the level of nitrotyrosine found in islets. In a diabetes-resistant NOD congenic mouse, the NOD.Lc7 mouse, we found increased beta cell proliferation and decreased apoptosis in islets. There are also lower levels of nitrotyrosine in islets of NOD.Lc7 mice than in NOD mice, suggesting that NOD.Lc7 islets are less susceptible to oxidative damage. We hypothesize that there may be a link between the ability of islet cells to regenerate and their resistance to oxidative stress.
Kathryn Haskins; Jennifer Kench; Katherine Powers; Brenda Bradley; Subbiah Pugazhenthi; Jane Reusch; Marcia McDuffie
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of investigative medicine : the official publication of the American Federation for Clinical Research     Volume:  52     ISSN:  1081-5589     ISO Abbreviation:  J. Investig. Med.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-03-01     Completed Date:  2004-03-17     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9501229     Medline TA:  J Investig Med     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  45-9     Citation Subset:  IM    
Department of Immunology, University of Colorado Health Sciences Center, 1400 Jackson Street, Denver, CO 80206, USA.
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MeSH Terms
Cell Division
Diabetes Mellitus, Type 1 / metabolism*
Islets of Langerhans / cytology,  physiology*
Mice, Congenic
Mice, Inbred NOD
Oxidative Stress / physiology*
Regeneration / physiology*
Tyrosine / analogs & derivatives*,  metabolism
Reg. No./Substance:
3604-79-3/3-nitrotyrosine; 55520-40-6/Tyrosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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