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Role of oxidative stress in the pathogenesis of preeclampsia.
MedLine Citation:
PMID:  20549510     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Hypertensive disorders of pregnancy are associated with an increased risk of maternal and fetal morbidity and mortality. The cause and the pathogenesis of the pregnancy-induced syndrome, preeclampsia, is still poorly understood. Published evidence of altered biomarkers for the endothelial dysfunction suggests that the initiating event in preeclampsia is the reduced placental perfusion, which leads to widespread dysfunction of the maternal vascular endothelium. This review focuses on the role of free radicals in generating the oxidative stress taking antioxidants into consideration which tend to overcome it as well as the role of placenta in preeclamptic pregnancy.
Authors:
Imran A Siddiqui; Anila Jaleel; Waleed Tamimi; Hanan M F Al Kadri
Publication Detail:
Type:  Journal Article     Date:  2010-06-15
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  282     ISSN:  1432-0711     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  469-74     Citation Subset:  IM    
Affiliation:
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh 11426, Kingdom of Saudi Arabia. siddiquiimra@gmail.com
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