| Role of oxidative stress in pancreatic inflammation. | |
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MedLine Citation:
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PMID: 18837654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reactive oxygen and reactive nitrogen species (ROS/RNS) have been implicated in the pathogenesis of acute and chronic pancreatitis. Clinical and basic science studies have indicated that ROS/RNS formation processes are intimately linked to the development of the inflammatory disorders. The detrimental effects of highly reactive ROS/RNS are mediated by their direct actions on biomolecules (lipids, proteins, and nucleic acids) and activation of proinflammatory signal cascades, which subsequently lead to activation of immune responses. The present article summarizes the possible sources of ROS/RNS formation and the detailed signaling cascades implicated in the pathogenesis of pancreatic inflammation, as observed in acute and chronic pancreatitis. A therapeutic ROS/RNS-scavenging strategy has been advocated for decades; however, clinical studies examining such approaches have been inconsistent in their results. Emerging evidence indicates that pancreatitis-inducing ROS/RNS generation may be attenuated by targeting ROS/RNS-generating enzymes and upstream mediators. |
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Authors:
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Po Sing Leung; Yuk Cheung Chan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: 11 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-11-03 Completed Date: 2008-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
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Languages: eng Pagination: 135-65 Citation Subset: IM |
Affiliation:
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Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China. psleung@cuhk.edu.hk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / metabolism Humans Inflammation / metabolism*, pathology Models, Biological Oxidative Stress* Pancreas / metabolism*, pathology Pancreatitis / metabolism Pancreatitis, Chronic / metabolism Reactive Nitrogen Species / metabolism Reactive Oxygen Species / metabolism Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Reactive Nitrogen Species; 0/Reactive Oxygen Species |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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