| Role of oral medications in spasticity management. | |
| | |
MedLine Citation:
|
PMID: 19769918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Oral medications are frequently used to manage spasticity. Some clinicians may believe that oral medications are a more conservative or "first-line" strategy to treat this condition. However, their use may lead to significant adverse events. Additionally, efficacy has not been well-established, in particular the ability of these medications to enhance functional outcome. The decision regarding the use of oral medications is further complicated by the fact that a number of different agents have been used for many different diagnoses. The relative dearth of well-controlled studies makes the choice of medications for a given clinical condition even more difficult. This article reviews the mechanisms of action of some of the medications that are more commonly used to treat spasticity and identifies some studies that may suggest efficacy, or lack thereof, for certain diagnoses. Because questions remain regarding the benefit of oral medications, potential side effects also are emphasized to help the reader consider both potential risks and benefits. The article is intended as a broad overview, rather than comprehensive review of the literature. |
| | |
Authors:
|
Thomas K Watanabe |
Related Documents
:
|
4758428 - Amenorrhoea after discontinuing combined oestrogen-progestogen oral contraceptives. 2068258 - Pemphigus vulgaris of the oral mucosa: report of two cases. 12355578 - Pharmacological and pharmacokinetic evaluation of celecoxib prodrugs in rats. 21633938 - Playing house. 9471138 - Secondary conditions following spinal cord injury in a population-based sample. 11640148 - Medical audit in the united kingdom: the past, present, and future. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: PM & R : the journal of injury, function, and rehabilitation Volume: 1 ISSN: 1934-1482 ISO Abbreviation: PM R Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-09-22 Completed Date: 2009-12-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101491319 Medline TA: PM R Country: United States |
Other Details:
|
Languages: eng Pagination: 839-41 Citation Subset: IM |
Affiliation:
|
Moss Rehab, Elkins Park, PA 19027, USA. watanabt@einstein.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Adrenergic alpha-Agonists / therapeutic use* GABA Modulators / therapeutic use* Humans Motor Neuron Disease / drug therapy Muscle Relaxants, Central / therapeutic use Muscle Spasticity / drug therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic alpha-Agonists; 0/GABA Modulators; 0/Muscle Relaxants, Central |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Surgical management of spasticity in persons with cerebral palsy.
Next Document: Chemodenervation and nerve blocks in the diagnosis and management of spasticity and muscle overactiv...