Document Detail


Role of omega-3 ethyl ester concentrate in reducing sudden cardiac death following myocardial infarction and in management of hypertriglyceridemia: an Indian consensus statement.
MedLine Citation:
PMID:  23102390     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Sudden cardiac death (SCD) is the most lethal manifestation of heart disease. In an Indian study the SCDs contribute about 10% of the total mortality and SCD post ST elevation myocardial infarction (MI) constitutes for about half of total deaths.
OBJECTIVE: Given the limitations of existing therapy there is a need for an effective, easy to use, broadly applicable and affordable intervention to prevent SCD post MI. Leading cardiologists from all over India came together to discuss the potential role of n-3 acid ethyl esters (90%) of eicosapentaenoic acid (EPA) 460 mg & docosahexaenoic acid (DHA) 380 mg in the management of post MI patients and those with hypertriglyceridemia.
RECOMMENDATIONS: Highly purified & concentrated omega-3 ethyl esters (90%) of EPA (460 mg) & DHA (380 mg) has clinically proven benefits in improving post MI outcomes (significant 15% risk reduction for all-cause mortality, 20% risk reduction for CVD and 45% risk reduction in SCD in GISSI-Prevenzione trial) and in reducing hypertriglyceridemia, and hence, represent an interesting option adding to the treatment armamentarium in the secondary prevention after MI based on its anti-arrhythmogenic effects and also in reducing hypertriglyceridemia.
Authors:
J J Dalal; R R Kasliwal; A L Dutta; J P S Sawhney; S S Iyengar; S Dani; N Desai; I Sathyamurthy; D Rao; A Menon; A Dasbiswas; G S Wander; M Chadha; M S Hiremath; D G Roy; V Gupta; N Shivakadaksham
Publication Detail:
Type:  Journal Article; Practice Guideline     Date:  2012-08-27
Journal Detail:
Title:  Indian heart journal     Volume:  64     ISSN:  0019-4832     ISO Abbreviation:  Indian Heart J     Publication Date:    2012 Sep-Oct
Date Detail:
Created Date:  2012-10-29     Completed Date:  2013-07-08     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  0374675     Medline TA:  Indian Heart J     Country:  India    
Other Details:
Languages:  eng     Pagination:  503-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Anti-Arrhythmia Agents / therapeutic use*
Consensus
Death, Sudden, Cardiac / etiology,  prevention & control*
Docosahexaenoic Acids / therapeutic use*
Drug Combinations
Eicosapentaenoic Acid / therapeutic use*
Humans
Hypertriglyceridemia / complications,  drug therapy*,  mortality
Hypolipidemic Agents / therapeutic use*
India / epidemiology
Myocardial Infarction / etiology,  mortality,  prevention & control*
Preventive Health Services*
Risk Assessment
Risk Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Drug Combinations; 0/Hypolipidemic Agents; 0/Omacor; 25167-62-8/Docosahexaenoic Acids; AAN7QOV9EA/Eicosapentaenoic Acid
Comments/Corrections

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