| The role of (18) fluoro-deoxy glucose combined position emission and computed tomography in the clinical management of anal squamous cell carcinoma. | |
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MedLine Citation:
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PMID: 20070338 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aim Anal squamous cell carcinoma (SCC) is uncommon in the western world but continues to increase in incidence. Optimal treatment and outcome are dependent upon pretreatment staging strategies. We evaluate the role of (18) fluoro-deoxyglucose ((18) FDG) combined position emission and computed tomography (PETCT) in the management of anal SCC. Method Patients with a histologically confirmed anal SCC underwent standard staging investigations, including computed tomography, Magnetic resonance imaging and examination under anaesthetic. A tumour, node, metastasis (TNM) system was used. All patients subsequently underwent additional whole-body (18) FDG PETCT scanning. Management was planned accordingly, blinded to (18) FDG PETCT findings, at a multidisciplinary meeting, and reviewed again following disclosure of PETCT results. Results Forty patients (24 men), with a median age of 57 years (range 38-87 years), were prospectively recruited. All primary tumours were (18) FDG avid. PETCT did not alter the T stage but did result in disease upstaging (N and M stages). Management was altered in five (12.5%) patients: one patient was identified to have an isolated distant metastasis, and four patients had (18) FDG-avid lymph nodes not otherwise detected, all of which were tumour-positive on fine needle aspiration cytology/biopsy. Conclusion PETCT upstages anal SCC and influences subsequent management. PETCT should be considered in the staging of anal SCC, although the definitive benefit of such a strategy requires further evaluation. |
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Authors:
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A H Engledow; J R A Skipworth; G Blackman; A Groves; J Bomanji; S J Warren; P J Ell; P B Boulos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland Volume: 13 ISSN: 1463-1318 ISO Abbreviation: Colorectal Dis Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-03-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883611 Medline TA: Colorectal Dis Country: England |
Other Details:
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Languages: eng Pagination: 532-7 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Colorectal Disease © 2011 The Association of Coloproctology of Great Britain and Ireland. |
Affiliation:
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Department of Colorectal and Laparoscopic Surgery Department of Clinical Oncology Department of Nuclear Medicine, University College London Hospital NHS Trust, London, UK Department of Colorectal and Laparoscopic Surgery, Chase Farm Hospital, Enfield, Middlesex, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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