| Role of the oesophagus in asthma induced by the ingestion of ice and acid. | |
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MedLine Citation:
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PMID: 3438894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twelve Asian patients with a history of asthma exacerbated by ingestion of ice and acidic drinks were selected for study. To determine the site of response to ingested ice and acid they were challenged with ice or dilute hydrochloric acid, which was orally retained on one day and swallowed on another. On a third day a placebo was given. The airway response was assessed by measuring FEV1 and the provocative concentration of histamine that reduced the FEV1 by at least 20% (PC20). There was no significant change in FEV1 or histamine PC20 after placebo or the orally retained challenges for the group as a whole or for any individual. After the ice and hydrochloric acid had been swallowed there was a small but statistically significant mean fall in FEV1, increasing to a maximum 90 minutes after ingestion, together with a significant increase in bronchial responsiveness. As conditioning of the inspired air would have been similar after orally retained and after swallowed ice or acid, the response is likely to be due to oesophageal stimulation. The mechanism of the response to oesophageal stimulation is unclear, but the slow time course seems to preclude a simple neural reflex. |
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Authors:
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N M Wilson; N Chudry; M Silverman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thorax Volume: 42 ISSN: 0040-6376 ISO Abbreviation: Thorax Publication Date: 1987 Jul |
Date Detail:
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Created Date: 1988-04-06 Completed Date: 1988-04-06 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0417353 Medline TA: Thorax Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 506-10 Citation Subset: IM |
Affiliation:
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Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, London. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acids
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adverse effects Adolescent Adult Asthma / etiology, physiopathology* Bronchi / physiopathology Bronchial Provocation Tests Child Cold Temperature / adverse effects Double-Blind Method Esophagus / physiopathology* Forced Expiratory Volume Humans Middle Aged Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Acids |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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