Document Detail

Role of the oesophagus in asthma induced by the ingestion of ice and acid.
MedLine Citation:
PMID:  3438894     Owner:  NLM     Status:  MEDLINE    
Twelve Asian patients with a history of asthma exacerbated by ingestion of ice and acidic drinks were selected for study. To determine the site of response to ingested ice and acid they were challenged with ice or dilute hydrochloric acid, which was orally retained on one day and swallowed on another. On a third day a placebo was given. The airway response was assessed by measuring FEV1 and the provocative concentration of histamine that reduced the FEV1 by at least 20% (PC20). There was no significant change in FEV1 or histamine PC20 after placebo or the orally retained challenges for the group as a whole or for any individual. After the ice and hydrochloric acid had been swallowed there was a small but statistically significant mean fall in FEV1, increasing to a maximum 90 minutes after ingestion, together with a significant increase in bronchial responsiveness. As conditioning of the inspired air would have been similar after orally retained and after swallowed ice or acid, the response is likely to be due to oesophageal stimulation. The mechanism of the response to oesophageal stimulation is unclear, but the slow time course seems to preclude a simple neural reflex.
N M Wilson; N Chudry; M Silverman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thorax     Volume:  42     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1988-04-06     Completed Date:  1988-04-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  506-10     Citation Subset:  IM    
Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, London.
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MeSH Terms
Acids / adverse effects
Asthma / etiology,  physiopathology*
Bronchi / physiopathology
Bronchial Provocation Tests
Cold Temperature / adverse effects
Double-Blind Method
Esophagus / physiopathology*
Forced Expiratory Volume
Middle Aged
Random Allocation
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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