Document Detail


Role for the obesity-related FTO gene in the cellular sensing of amino acids.
MedLine Citation:
PMID:  23359686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SNPs in the first intron of FTO (fat mass and obesity associated) are strongly associated with human obesity. While it is not yet formally established that this effect is mediated through the actions of the FTO protein itself, loss of function mutations in FTO or its murine homologue Fto result in severe growth retardation, and mice globally overexpressing FTO are obese. The mechanisms through which FTO influences growth and body composition are unknown. We describe a role for FTO in the coupling of amino acid levels to mammalian target of rapamycin complex 1 signaling. These findings suggest that FTO may influence body composition through playing a role in cellular nutrient sensing.
Authors:
Pawan Gulati; Man Ka Cheung; Robin Antrobus; Chris D Church; Heather P Harding; Yi-Chun Loraine Tung; Debra Rimmington; Marcella Ma; David Ron; Paul J Lehner; Frances M Ashcroft; Roger D Cox; Anthony P Coll; Stephen O'Rahilly; Giles S H Yeo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-28
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  110     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-13     Completed Date:  2013-04-08     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2557-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism*
Animals
Body Composition / genetics*
Cell Fractionation
Chromatography, Liquid
Electrophoresis, Polyacrylamide Gel
Fibroblasts
HEK293 Cells
Humans
Immunoprecipitation
Mice
Obesity / genetics*
Polymorphism, Single Nucleotide / genetics
Proteins / genetics*,  metabolism*
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction / genetics*
TOR Serine-Threonine Kinases / metabolism*
Tandem Mass Spectrometry
Grant Support
ID/Acronym/Agency:
084655//Wellcome Trust; 084812//Wellcome Trust; 093136//Wellcome Trust; 100140//Wellcome Trust; G0900554//Medical Research Council; G9824984//Medical Research Council; MC_U142661184//Medical Research Council
Chemical
Reg. No./Substance:
0/Amino Acids; 0/FTO protein, human; 0/Proteins; EC 2.7.1.1/TOR Serine-Threonine Kinases; EC 2.7.1.1/mTOR protein, mouse
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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