| Role for the obesity-related FTO gene in the cellular sensing of amino acids. | |
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MedLine Citation:
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PMID: 23359686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SNPs in the first intron of FTO (fat mass and obesity associated) are strongly associated with human obesity. While it is not yet formally established that this effect is mediated through the actions of the FTO protein itself, loss of function mutations in FTO or its murine homologue Fto result in severe growth retardation, and mice globally overexpressing FTO are obese. The mechanisms through which FTO influences growth and body composition are unknown. We describe a role for FTO in the coupling of amino acid levels to mammalian target of rapamycin complex 1 signaling. These findings suggest that FTO may influence body composition through playing a role in cellular nutrient sensing. |
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Authors:
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Pawan Gulati; Man Ka Cheung; Robin Antrobus; Chris D Church; Heather P Harding; Yi-Chun Loraine Tung; Debra Rimmington; Marcella Ma; David Ron; Paul J Lehner; Frances M Ashcroft; Roger D Cox; Anthony P Coll; Stephen O'Rahilly; Giles S H Yeo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2013-01-28 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 110 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-02-13 Completed Date: 2013-04-08 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 2557-62 Citation Subset: IM |
Affiliation:
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University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom. pg367@cam.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Animals Body Composition / genetics* Cell Fractionation Chromatography, Liquid Electrophoresis, Polyacrylamide Gel Fibroblasts HEK293 Cells Humans Immunoprecipitation Mice Obesity / genetics* Polymorphism, Single Nucleotide / genetics Proteins / genetics*, metabolism* Reverse Transcriptase Polymerase Chain Reaction Signal Transduction / genetics* TOR Serine-Threonine Kinases / metabolism* Tandem Mass Spectrometry |
| Grant Support | |
ID/Acronym/Agency:
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093136//Wellcome Trust; G9824984//Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/FTO protein, human; 0/Proteins; EC 2.7.1.1/TOR Serine-Threonine Kinases; EC 2.7.1.1/mTOR protein, mouse |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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