Document Detail

Role for the obesity-related FTO gene in the cellular sensing of amino acids.
MedLine Citation:
PMID:  23359686     Owner:  NLM     Status:  MEDLINE    
SNPs in the first intron of FTO (fat mass and obesity associated) are strongly associated with human obesity. While it is not yet formally established that this effect is mediated through the actions of the FTO protein itself, loss of function mutations in FTO or its murine homologue Fto result in severe growth retardation, and mice globally overexpressing FTO are obese. The mechanisms through which FTO influences growth and body composition are unknown. We describe a role for FTO in the coupling of amino acid levels to mammalian target of rapamycin complex 1 signaling. These findings suggest that FTO may influence body composition through playing a role in cellular nutrient sensing.
Pawan Gulati; Man Ka Cheung; Robin Antrobus; Chris D Church; Heather P Harding; Yi-Chun Loraine Tung; Debra Rimmington; Marcella Ma; David Ron; Paul J Lehner; Frances M Ashcroft; Roger D Cox; Anthony P Coll; Stephen O'Rahilly; Giles S H Yeo
Related Documents :
24187996 - Protodeboronation of ortho- and para-phenol boronic acids and application to ortho- and...
22932126 - Folic acid facilitates in vitro maturation of mouse and xenopus laevis oocytes.
25138176 - Cyp-13a12 of the nematode c. elegans is a pufa-epoxygenase involved in behavioural resp...
23457116 - Electricity storage in biofuels: selective electrocatalytic reduction of levulinic acid...
20148096 - The role of different hyaluronic acids in the articular cartilage of rabbit.
6796656 - Dopamine metabolism following irreversible inactivation of aromatic amino acid decarbox...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-28
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  110     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-13     Completed Date:  2013-04-08     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2557-62     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acids / metabolism*
Body Composition / genetics*
Cell Fractionation
Chromatography, Liquid
Electrophoresis, Polyacrylamide Gel
HEK293 Cells
Obesity / genetics*
Polymorphism, Single Nucleotide / genetics
Proteins / genetics*,  metabolism*
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction / genetics*
TOR Serine-Threonine Kinases / metabolism*
Tandem Mass Spectrometry
Grant Support
084655//Wellcome Trust; 084812//Wellcome Trust; 093136//Wellcome Trust; 100140//Wellcome Trust; G0900554//Medical Research Council; G9824984//Medical Research Council; MC_U142661184//Medical Research Council
Reg. No./Substance:
0/Amino Acids; 0/FTO protein, human; 0/Proteins; EC Serine-Threonine Kinases; EC protein, mouse

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome.
Next Document:  Stick-slip friction and wear of articular joints.