Document Detail

Role of nutrition in toxic injury.
MedLine Citation:
PMID:  10641128     Owner:  NLM     Status:  MEDLINE    
The importance of nutrition in protecting the living organism against the potentially lethal effects of reactive oxygen species and toxic environmental chemicals has recently been realized. This new perspective has prompted re-evaluation of the food constituents of human diet from the point of view of their nutritional adequacy, deficiency and toxicity. The biological antioxidant defense system is an integrated array of enzymes, antioxidants and free radical scavengers. These include glutathione reductase, glutathione-s-transferase, glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, superoxide dismutase (SOD) and catalase, together with the antioxidant vitamins C, E and A. The individual components of this system get utilized in various physiological process and for chemoprotection and therefore require replenishment from the diet. Other components of the diet like carbohydrates, proteins and lipids are important for maintaining the levels of various enzymes required in body's defense system providing protection against carcinogens. However, the emerging newer concepts focus on the role of trace elements and other dietary components in antioxidant defense and detoxification mechanisms. Trace elements like Iron, zinc magnesium, selenium, copper, and manganese are some of the elements involved in antioxidant defense mechanisms. Inadequate intake of these nutrients has been associated with ischemic heart disease, arthritis, stroke and cancer, where pathogenic role of free radicals is suggested. Further the importance of diet in the prevention of chemical induced toxicity can not be undetermined. Recent reports on the role of bioflavonoids as antioxidents and their potential use to reduce the risks of coronary heart disease and cancer in human beings have opened a new arena for future research. Induction of the cytochrome P450 isoenzymes by food pyrolysis, mutagens, alcohol and fasting, on the other hand is reported to contribute to chemical toxicity and carcinogenecity. Certain chemicals moieties in the food are mutagenic and carcinogenic.
S B Lall; B Singh; K Gulati; S D Seth
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  37     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  2000-02-14     Completed Date:  2000-02-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  109-16     Citation Subset:  IM    
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi.
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MeSH Terms
Antioxidants / metabolism
Diet / adverse effects
Energy Metabolism
Food Contamination
Nutritional Physiological Phenomena*
Reactive Oxygen Species / metabolism
Xenobiotics / toxicity*
Reg. No./Substance:
0/Antioxidants; 0/Reactive Oxygen Species; 0/Xenobiotics
Erratum In:
Indian J Exp Biol 1999 May;37(5):followi

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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