| Role of nuclear factor (erythroid-derived 2)-like 2 in metabolic homeostasis and insulin action: A novel opportunity for diabetes treatment? | |
| | |
MedLine Citation:
|
PMID: 22253942 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Redox balance is fundamentally important for physiological homeostasis. Pathological factors that disturb this dedicated balance may result in oxidative stress, leading to the development or aggravation of a variety of diseases, including diabetes mellitus, cardiovascular diseases, metabolic syndrome as well as inflammation, aging and cancer. Thus, the capacity of endogenous free radical clearance can be of patho-physiological importance; in this regard, the major reactive oxygen species defense machinery, the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) system needs to be precisely modulated in response to pathological alterations. While oxidative stress is among the early events that lead to the development of insulin resistance, the activation of Nrf2 scavenging capacity leads to insulin sensitization. Furthermore, Nrf2 is evidently involved in regulating lipid metabolism. Here we summarize recent findings that link the Nrf2 system to metabolic homeostasis and insulin action and present our view that Nrf2 may serve as a novel drug target for diabetes and its complications. |
| | |
Authors:
|
Zhi-Wen Yu; Dan Li; Wen-Hua Ling; Tian-Ru Jin |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: World journal of diabetes Volume: 3 ISSN: 1948-9358 ISO Abbreviation: World J Diabetes Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101547524 Medline TA: World J Diabetes Country: China |
Other Details:
|
Languages: eng Pagination: 19-28 Citation Subset: - |
Affiliation:
|
Zhi-Wen Yu, Dan Li, Wen-Hua Ling, Tian-Ru Jin, Guandong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, Public Health Institute, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pathophysiological role and therapeutic implications of inflammation in diabetic nephropathy.
Next Document: Gastrointestinal and Cardiovascular Risk of Nonsteroidal Anti-inflammatory Drugs.