| Role of novel mediators of inflammation in left ventricular remodeling in patients with acute myocardial infarction: do they affect the outcome of patients? | |
| | |
MedLine Citation:
|
PMID: 17351157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Left ventricular (LV) remodeling after acute myocardial infarction (AMI) is a major mechanism for cardiovascular death and disability. A significant number of post-MI patients develop progressive left ventricular enlargement and heart failure and many require heart transplantation and ventricular assist devices. Understanding of the basic mechanisms regulating the reaction to injury is crucial for the development of site-specific cell biological strategies of intervention to both reduce injury and promote repair. To determine whether there are new inflammatory markers having a role in structural remodeling after AMI in patients who applied to the emergency department of this hospital with severe chest pain at the first 12 hours, the authors measured the levels of C-reactive protein (CRP), macrophage colony-stimulating factor (M-CSF) and interleukin-3 (IL-3) in patients with AMI at hospital admission and on day 5. They measured plasma CRP concentrations by using highly sensitive CRP reagent with the immunonephelometric method, and plasma M-CSF and IL-3 concentrations with the help of a commercial enzyme-linked immunoassay test in 30 patients with AMI. Mean plasma CRP, M-CSF, and IL-3 concentrations at admission to the hospital were significantly higher than those on day 5 (5.0 -/+ 3.1 mg/dL, 119.4 -/+ 103.6 pg/mL, and 155.1 -/+ 83.4 ng/mL, respectively, p < 0.001 for each value). CRP, M-CSF, and IL-3 were all increased in patients with AMI. These findings suggest that these are new inflammatory markers, which may have important roles in LV remodeling after AMI. |
| | |
Authors:
|
Hüseyin Oren; A Riza Erbay; Mustafa Balci; Sengül Cehreli |
Related Documents
:
|
20922537 - Effects of telmisartan on markers of ventricular remodeling in patients with acute myoc... 19706597 - Microrna expression signature and the role of microrna-21 in the early phase of acute m... 8691397 - High prevalence of smoking in young patients with acute myocardial infarction. 11704377 - The association between white blood cell count and acute myocardial infarction mortalit... 6226727 - Coronary artery spasm at the site of angioplasty in the first 2 months after successful... 10935427 - New perspectives in the drug treatment of kawasaki disease. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Angiology Volume: 58 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 2007 Feb-Mar |
Date Detail:
|
Created Date: 2007-03-12 Completed Date: 2007-04-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
|
Languages: eng Pagination: 45-54 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Türkiye Yüksek Ihtisas Hospital, Ankara. husoren@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Biological Markers / blood C-Reactive Protein / analysis Fibrinogen / analysis Humans Interleukin-3 / blood Macrophage Colony-Stimulating Factor / blood Male Middle Aged Myocardial Infarction / blood*, physiopathology Outcome Assessment (Health Care)* Patient Admission Ventricular Dysfunction, Left / blood*, physiopathology Ventricular Remodeling / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Interleukin-3; 81627-83-0/Macrophage Colony-Stimulating Factor; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The open artery hypothesis: beneficial effects and long-term prognostic importance of patency of the...
Next Document: Effects of statins on restenosis after coronary stent implantation.