Document Detail

Role of noradrenergic system in the mechanism of action of endogenous neurotoxin 1,2,3,4-tetrahydroisoquinoline: biochemical and functional studies.
MedLine Citation:
PMID:  12020040     Owner:  NLM     Status:  MEDLINE    
It is well recognized that 1,2,3,4-tetrahydroisoquinoline (TIQ) is a substance capable of inducing in animals a syndrome, regarded as an animal model of Parkinson's disease. This study was designed to evaluate the effect of the endogenous neurotoxin TIQ on the brain noradrenaline (NA) metabolism in mice and on an arterial blood pressure in rats. It was shown for the first time that TIQ significantly increased NA metabolism, induced NA release and raised the level of its final metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG), in mouse brain. The comparative biochemical studies using specific agonist (clonidine) and antagonist (yohimbine) of alpha2-adrenergic receptors ligands have shown that observed biochemical effects were similar to those produced by alpha2-adrenergic antagonist, yohimbine. In functional studies, the systolic and diastolic blood pressure was measured using a non-invasive blood pressure transducer. Both acute and multiple treatment with TIQ produced a strong hypotensive effect, having decreased both systolic and diastolic blood pressure in rats. Development of tolerance to the hypotensive effect was observed after multiple treatment with TIQ. The data coming from these experimental studies apparently suggest an important role of the noradrenergic system in the mechanism of action of endogenous compounds from TIQ group. The results may also support the hypothesis assuming a causal relationship between noradrenergic dennervation, activity of the nigrostriatal dopamine system, and some clinical manifestation of Parkinson's disease.
Jerzy Michaluk; Anna Krygowska-Wajs; Beata Karolewicz; Lucyna Antkiewicz-Michaluk
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Polish journal of pharmacology     Volume:  54     ISSN:  1230-6002     ISO Abbreviation:  Pol J Pharmacol     Publication Date:    2002 Jan-Feb
Date Detail:
Created Date:  2002-05-21     Completed Date:  2002-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9313882     Medline TA:  Pol J Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  19-25     Citation Subset:  IM    
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology
Adrenergic alpha-Antagonists / pharmacology
Blood Pressure / drug effects*
Brain / metabolism*
Brain Chemistry / drug effects
Clonidine / pharmacology
Injections, Intraperitoneal
Isoquinolines / toxicity*
Neurotoxins / toxicity*
Norepinephrine / metabolism*
Parkinson Disease / physiopathology
Rats, Wistar
Yohimbine / pharmacology
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 0/Isoquinolines; 0/Neurotoxins; 0/Tetrahydroisoquinolines; 146-48-5/Yohimbine; 4205-90-7/Clonidine; 51-41-2/Norepinephrine; 91-21-4/1,2,3,4-tetrahydroisoquinoline

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