| Role of noradrenaline and 5-hydroxytryptamine in tetrahydronaphthylamine-induced temperature changes in the rat. | |
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MedLine Citation:
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PMID: 4257629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Intraperitoneal administration of graded doses of tetrahydronaphthylamine (THN) to rats caused a dose dependent decrease in body temperature.2. Intracisternal injection of graded doses of THN induced hypothermia, and implantation of crystalline THN rostral to the medial preoptic area and caudal to the striatum, caused hyperthermia.3. Pretreatment of the rats with a MAO inhibitor changed the hypothermia into hyperthermia.4. Intraperitoneal injection of 5-hydroxytryptophan caused a hypothermia which could be reversed into hyperthermia when the rats were pretreated with a MAO inhibitor.5. Pretreatment with parachlorophenylalanine enhanced the THN-induced hypothermia.6. Depletion of brain monoamines by Ro-4-1284 in combination with an inhibition of the biosynthesis of noradrenaline (diethyldithiocarbamate) changed the THN-induced hypothermia into hyperthermia.7. It is concluded that THN affects body temperature in rats by two central mechanisms, viz. a decrease mediated by noradrenaline, probably in the hypothalamus, and an increase which might be mediated by 5-hydroxytryptamine rostral to the medial preoptic area. |
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Authors:
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J Bruinvels; G C Kemper |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 43 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1971 Sep |
Date Detail:
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Created Date: 1972-03-30 Completed Date: 1972-03-30 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects* Drug Synergism Fenclonine / pharmacology Fever / chemically induced Hypothalamus / physiology Hypothermia / chemically induced Injections, Intraperitoneal Male Naphthalenes / antagonists & inhibitors, pharmacology* Nialamide / pharmacology Norepinephrine / biosynthesis, pharmacology* Quinolizines / pharmacology Rats Serotonin / pharmacology* Tranquilizing Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Naphthalenes; 0/Quinolizines; 0/Tranquilizing Agents; 50-67-9/Serotonin; 51-12-7/Nialamide; 51-41-2/Norepinephrine; 7424-00-2/Fenclonine |
| Comments/Corrections | |
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