Document Detail

Role of nonallergic hypersensitivity reactions in children with chronic urticaria.
MedLine Citation:
PMID:  9860240     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: IgE-independent (pseudoallergic) reactions to food and food ingredients are common in a subgroup of adult patients with chronic urticaria, who have daily spontaneous occurrence of wheals. However, for children with chronic urticaria (duration longer than 6 weeks, no physical influence), no data on the importance of pseudoallergen-induced chronic urticaria are available. Therefore, we investigated the role of nonallergic hypersensitivity to food in all children seen with chronic continuous urticaria in our two clinics over the last 2 years (n = 16). METHODS: All patients were given a low-pseudoallergen diet for 3 weeks followed by provocation with food rich in pseudoallergens. To identify the main eliciting agents, a subgroup of responders was exposed to food additives by double-blind, placebo-controlled food challenges. RESULTS: Pseudoallergen-induced urticaria was diagnosed in 12 cases (75%). Reactions occurred mainly to coloring agents and preservatives, but also to monosodium glutamate and a sweetener (saccharin/cyclamate). CONCLUSIONS: These results confirm that nonallergic hypersensitivity reactions play a role in children with chronic urticaria, although the latter disease is rare at that age. In children, food additives, especially coloring agents and preservatives, appear to play a more important role in eliciting nonallergic hypersensitivity reactions than in adult patients, where naturally occurring pseudoallergens in fruits and vegetables are mainly responsible.
I Ehlers; B Niggemann; C Binder; T Zuberbier
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Allergy     Volume:  53     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-02-25     Completed Date:  1999-02-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1074-7     Citation Subset:  IM    
Department of Dermatology, Charité, Humboldt-University Berlin, Germany.
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MeSH Terms
Child, Preschool
Chronic Disease
Diet / adverse effects
Double-Blind Method
Food Hypersensitivity / complications*,  diet therapy
Longitudinal Studies
Prospective Studies
Urticaria / diet therapy,  etiology*
Comment In:
Allergy. 1998 Nov;53(11):1011-2   [PMID:  9860233 ]

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