Document Detail


Role of nitric oxide and prostaglandins in the bone formation response to mechanical loading.
MedLine Citation:
PMID:  11064853     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nitric oxide and prostaglandins are crucial early mediators in mechanically induced bone formation. They are also responsible for the associated induction of gene expression of c-fos and IGF-1 in osteocytes, key mechanosensory cells in bone. Insight into the cellular and molecular mechanisms underlying bone formation has important implications for the maintenance of structural competence of bone.
Authors:
J W Chow
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Exercise and sport sciences reviews     Volume:  28     ISSN:  0091-6331     ISO Abbreviation:  Exerc Sport Sci Rev     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-02-15     Completed Date:  2001-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375434     Medline TA:  Exerc Sport Sci Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  185-8     Citation Subset:  IM    
Affiliation:
Histopathology Department, St George's Hospital Medical School, London, UK. j.chow@sghms.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Development / physiology*
Bone Remodeling / physiology*
Gene Expression
Genes, fos / genetics
Nitric Oxide / physiology*
Osteocytes / cytology
Osteogenesis / physiology
Physical Stimulation
Prostaglandins / physiology*
Rats
Stress, Mechanical
Time Factors
Chemical
Reg. No./Substance:
0/Prostaglandins; 10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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