Document Detail


Role of nitric oxide in the renin and heart rate responses to beta-adrenergic stimulation.
MedLine Citation:
PMID:  8282375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies in vitro and in vivo have implicated nitric oxide in the control of renin secretion. In the present study, the effect of inhibition of nitric oxide synthesis with NG-nitro-L-arginine methyl ester hydrochloride (L-NAME) on the renin secretory response to beta-adrenergic stimulation was investigated in conscious, chronically prepared rabbits. Intravenous infusion of isoproterenol at 0.02 microgram.kg-1 x min-1 for 30 minutes increased mean arterial pressure by 5 mm Hg (P < .05), heart rate by 51 beats per minute (P < .001), and plasma renin activity by 56% (P < .001). Intravenous infusion of L-NAME at 0.5 mg.kg-1 x min-1 increased mean arterial pressure by 6 mm Hg (P < .01) and decreased heart rate by 15 beats per minute (P < .01) and plasma renin activity by 31% (P < .05). L-NAME reduced the heart rate response to isoproterenol by 50% and inhibited the renin response. Infusion of isoproterenol at 0.05 microgram.kg-1 x min-1 did not change blood pressure but increased heart rate by 62 beats per minute (P < .001) and plasma renin activity by 283% (P < .001). Treatment with L-NAME again suppressed the heart rate response to isoproterenol and inhibited the renin response. Intravenous infusion of the nitric oxide donor nitroprusside at 2 micrograms.kg-1.min-1 in the presence of L-NAME decreased mean arterial pressure by 7 mm Hg (P < .05), increased heart rate by 14 beats per minute (P < .05), but did not change plasma renin activity. Nitroprusside fully restored the heart rate response to isoproterenol and partially restored the renin response.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
I A Reid; H Bui; L Chou
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  23     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-02-16     Completed Date:  1994-02-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I49-53     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of California, San Francisco 94143-0444.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Arginine / administration & dosage,  analogs & derivatives*,  pharmacology
Blood Pressure / drug effects*
Heart Rate / drug effects*
Infusions, Intravenous
Isoproterenol / administration & dosage,  pharmacology*
Male
NG-Nitroarginine Methyl Ester
Nitric Oxide / antagonists & inhibitors,  physiology*
Nitroprusside / administration & dosage,  pharmacology
Rabbits
Receptors, Adrenergic, beta / drug effects,  physiology*
Renin / blood,  drug effects,  secretion*
Grant Support
ID/Acronym/Agency:
HL-29714/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 10102-43-9/Nitric Oxide; 15078-28-1/Nitroprusside; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; 7683-59-2/Isoproterenol; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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