Document Detail

Role of nitric oxide in the relationship of pancreatic blood flow and exocrine secretion in cats.
MedLine Citation:
PMID:  7535273     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Recent studies have suggested that, in the gastrointestinal tract, nitric oxide is an important mediator of alterations in blood flow and, in some organs, a second messenger involved in secretion. This study examined the role of NO in changes in pancreatic blood flow associated with basal and stimulated pancreatic exocrine secretion. METHODS: In anesthetized cats, we determined the effects of the NO synthase inhibitor NG-monomethyl-L-arginine (10 mg/kg) and the NO donor sodium nitroprusside (10 on pancreatic secretion and blood flow (hydrogen gas clearance). RESULTS: NG-monomethyl-L-arginine had no effect on the increase in blood flow associated with secretin stimulation (271 +/- 52 vs. 290 +/- 50 mL.min-1.100 g-1) but reduced that associated with cholecystokinin stimulation (189 +/- 17 vs. 53 +/- 15 mL.min-1.100 g-1; P < 0.001). In contrast, NG-monomethyl-L-arginine significantly reduced both secretin- and cholecystokinin-stimulated secretion. Sodium nitroprusside had no effect on basal blood flow but significantly increased secretion. CONCLUSIONS: NO has a selective role in mediating changes in pancreatic perfusion and secretion. It seems to be important in stimulus-secretion coupling with both secretin and cholecystokinin but is only responsible for the accompanying increase in pancreatic blood flow with cholecystokinin.
A G Patel; M T Toyama; T N Nguyen; G A Cohen; L J Ignarro; H A Reber; S W Ashley
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  108     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-05-02     Completed Date:  1995-05-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1215-20     Citation Subset:  AIM; IM    
Department of Surgery, Sepulveda Veterans Administration Medical Center, California.
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MeSH Terms
Amino Acid Oxidoreductases / antagonists & inhibitors
Arginine / analogs & derivatives,  pharmacology
Cholecystokinin / pharmacology
Microcirculation / drug effects,  physiology
Nitric Oxide / physiology*
Nitric Oxide Synthase
Nitroprusside / pharmacology
Pancreas / blood supply*,  drug effects,  secretion*
Regional Blood Flow / drug effects
Secretin / pharmacology
Reg. No./Substance:
10102-43-9/Nitric Oxide; 1393-25-5/Secretin; 15078-28-1/Nitroprusside; 17035-90-4/omega-N-Methylarginine; 74-79-3/Arginine; 9011-97-6/Cholecystokinin; EC Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases

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