| Role of nitric oxide in the relationship of pancreatic blood flow and exocrine secretion in cats. | |
| | |
MedLine Citation:
|
PMID: 7535273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND/AIMS: Recent studies have suggested that, in the gastrointestinal tract, nitric oxide is an important mediator of alterations in blood flow and, in some organs, a second messenger involved in secretion. This study examined the role of NO in changes in pancreatic blood flow associated with basal and stimulated pancreatic exocrine secretion. METHODS: In anesthetized cats, we determined the effects of the NO synthase inhibitor NG-monomethyl-L-arginine (10 mg/kg) and the NO donor sodium nitroprusside (10 micrograms.kg-1.min-1) on pancreatic secretion and blood flow (hydrogen gas clearance). RESULTS: NG-monomethyl-L-arginine had no effect on the increase in blood flow associated with secretin stimulation (271 +/- 52 vs. 290 +/- 50 mL.min-1.100 g-1) but reduced that associated with cholecystokinin stimulation (189 +/- 17 vs. 53 +/- 15 mL.min-1.100 g-1; P < 0.001). In contrast, NG-monomethyl-L-arginine significantly reduced both secretin- and cholecystokinin-stimulated secretion. Sodium nitroprusside had no effect on basal blood flow but significantly increased secretion. CONCLUSIONS: NO has a selective role in mediating changes in pancreatic perfusion and secretion. It seems to be important in stimulus-secretion coupling with both secretin and cholecystokinin but is only responsible for the accompanying increase in pancreatic blood flow with cholecystokinin. |
| | |
Authors:
|
A G Patel; M T Toyama; T N Nguyen; G A Cohen; L J Ignarro; H A Reber; S W Ashley |
Related Documents
:
|
7296783 - The effects of hypoproteinemia on blood-to-lymph fluid transport in sheep lung. 6643693 - Effects of furosemide on biliary secretion, pancreatic blood flow, and pancreatic exocr... 17895973 - Do haematophagous bugs assess skin surface temperature to detect blood vessels? |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Gastroenterology Volume: 108 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1995 Apr |
Date Detail:
|
Created Date: 1995-05-02 Completed Date: 1995-05-02 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1215-20 Citation Subset: AIM; IM |
Affiliation:
|
Department of Surgery, Sepulveda Veterans Administration Medical Center, California. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acid Oxidoreductases
/
antagonists & inhibitors Animals Arginine / analogs & derivatives, pharmacology Cats Cholecystokinin / pharmacology Female Male Microcirculation / drug effects, physiology Nitric Oxide / physiology* Nitric Oxide Synthase Nitroprusside / pharmacology Pancreas / blood supply*, drug effects, secretion* Regional Blood Flow / drug effects Secretin / pharmacology omega-N-Methylarginine |
| Chemical | |
Reg. No./Substance:
|
10102-43-9/Nitric Oxide; 1393-25-5/Secretin; 15078-28-1/Nitroprusside; 17035-90-4/omega-N-Methylarginine; 74-79-3/Arginine; 9011-97-6/Cholecystokinin; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A unique subset of rat and human intestinal villus cells express the cystic fibrosis transmembrane c...
Next Document: Effect of a wheat amylase inhibitor on canine carbohydrate digestion, gastrointestinal function, and...