| Role of nitric oxide in the pathophysiology of heart failure. | |
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MedLine Citation:
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PMID: 12652158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitric oxide (NO) plays critical roles in the regulation of integrated cardiac and vascular function and homeostasis. An understanding of the physiologic role and relative contribution of the three NO synthase isoforms (neuronal--NOS1, inducible--NOS2, and endothelial--NOS3) is imperative to comprehend derangements of the NO signaling pathway in the failing cardiovascular system. Several theories of NO and its regulation have developed as explanations for the divergent observations from studies in health and disease states. Here we review the physiologic and pathophysiologic influence of NO on cardiac function, in a framework that considers several theories of altered NO signaling in heart failure. We discuss the notion of spatial compartmentalization of NO signaling within the myocyte in an effort to reconcile many controversies about derangements in the influences of NO in the heart and vasculature. |
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Authors:
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Hunter C Champion; Michel W Skaf; Joshua M Hare |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Heart failure reviews Volume: 8 ISSN: 1382-4147 ISO Abbreviation: Heart Fail Rev Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-03-24 Completed Date: 2003-06-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9612481 Medline TA: Heart Fail Rev Country: United States |
Other Details:
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Languages: eng Pagination: 35-46 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Endothelium, Vascular
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cytology,
metabolism,
physiopathology Heart Failure / physiopathology* Humans Myocytes, Cardiac / metabolism Nitric Oxide / physiology* Signal Transduction / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL65455/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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