Document Detail

Role of nitric oxide in the nucleus of the solitary tract of rats.
MedLine Citation:
PMID:  9666137     Owner:  NLM     Status:  MEDLINE    
We have determined the role of nitric oxide (NO) in the nucleus of the solitary tract (NTS) of normotensive Wistar rats. The unilateral microinjection of Nomega-nitro-l-arginine methyl ester (10 nmol) to block the synthesis of NO into the NTS significantly decreased the arterial pressure, heart rate (HR) and renal sympathetic nerve activity (RSNA) (-19+/-2 mmHg, -23+/-5 beats/min, -30+/-2%, respectively). The microinjection of carboxy-2-phenyl-4,4,5, 5-tetramethylimidazoline-1-oxyl 3-oxide (Carboxy PTIO) (trapper of NO; 0.1 nmol) into the NTS also decreased arterial pressure and RSNA. Conversely, the microinjection of Et2N[N(O)NO]Na (NOC 18) (NO donor; 10 nmol) caused increases in arterial pressure, HR and RSNA (+14+/-2 mmHg, +11+/-2 beats/min, +38+/-7%, respectively), which was inhibited by the pre-microinjection of Carboxy PTIO (0.1 nmol). On the other hand, not only l-arginine (10 nmol) but also d-arginine (10 nmol), which is inactive to produce NO, significantly decreased the arterial pressure and RSNA. These results suggest that (1) NO acts at the NTS to increase the arterial pressure and RSNA, and (2) the microinjection of l-arginine as well as d-arginine led to decreases in arterial pressure and RSNA that were not mediated by the formation of NO in the NTS.
K Matsumura; T Tsuchihashi; S Kagiyama; I Abe; M Fujishima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  798     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-09-11     Completed Date:  1998-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  232-8     Citation Subset:  IM    
Copyright Information:
Copyright 1998 Elsevier Science B.V. All rights reserved.
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.
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MeSH Terms
Arginine / pharmacology
Benzoates / pharmacology
Blood Pressure / drug effects
Enzyme Inhibitors / pharmacology
Heart Rate / drug effects
Imidazoles / pharmacology
Kidney / innervation
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide / physiology*
Nitroso Compounds / pharmacology
Rats, Wistar
Solitary Nucleus / drug effects,  physiology*
Sympathetic Nervous System / drug effects
Reg. No./Substance:
0/Benzoates; 0/Enzyme Inhibitors; 0/Imidazoles; 0/NOC 18; 0/Nitroso Compounds; 10102-43-9/Nitric Oxide; 145757-47-7/1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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