Document Detail


Role of nitric oxide in insulin-dependent diabetes mellitus-related vascular complications.
MedLine Citation:
PMID:  7785258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with insulin-dependent diabetes mellitus are at high risk for vascular disorders such as hypertension, nephropathy, and retinopathy. The most common cause of morbidity and mortality in patients with insulin-dependent diabetes is vascular disease. Despite ongoing research, the pathogenesis of vascular disease in diabetes remains unclear. In recent years, numerous investigators have examined the role of the endothelium-derived relaxing factor, nitric oxide, in the disease state of hypertension and its complications. We review the role of nitric oxide in the development of diabetes-related vascular disease and discuss findings suggesting that nitric oxide metabolism and vascular responsiveness to nitric oxide are altered in diabetes. Patients with diabetes may benefit from therapy that addresses this pathogenic deficiency.
Authors:
O Traub; R Van Bibber
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Western journal of medicine     Volume:  162     ISSN:  0093-0415     ISO Abbreviation:  West. J. Med.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-07-20     Completed Date:  1995-07-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0410504     Medline TA:  West J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  439-45     Citation Subset:  AIM; IM    
Affiliation:
Dept. of Physiology and Biophysics, University of Washington School of Medicine, Seattle 98195, USA.
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MeSH Terms
Descriptor/Qualifier:
Diabetes Mellitus, Type 1 / complications*
Diabetic Angiopathies / physiopathology*
Humans
Nitric Oxide / physiology*
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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