| Role of nitric oxide in gastric hyperemia induced by central vagal stimulation. | |
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MedLine Citation:
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PMID: 8447409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of N omega-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthesis, on the vagal cholinergic increase in gastric mucosal blood flow (GMBF) and acid secretion induced by intracisternal injection of the thyrotropin-releasing hormone (TRH) analogue, RX 77368, were studied. GMBF and acid secretion were measured simultaneously by the hydrogen gas clearance technique and titration of gastric perfusate in urethan-anesthetized rats. RX 77368 (30 ng) injected intracisternally stimulated gastric acid secretion and GMBF for 90 and 180 min respectively. GMBF was increased from basal 63 +/- 4 to 166 +/- 14 ml.min-1.100 g-1 at 60 min postinjection. L-NAME (3 mg/kg) injected intravenously 15 min before RX 77368 completely prevented the increase in GMBF induced by the TRH analogue, whereas the acid response was not modified. The effect of L-NAME was reversed by L-arginine but not by the stereoisomer D-arginine. These results show that the increase in GMBF, but not the stimulation of acid secretion, induced by central vagal activation is mediated through a product of L-arginine-NO pathway. |
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Authors:
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T Tanaka; P Guth; Y Taché |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 264 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1993 Feb |
Date Detail:
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Created Date: 1993-04-02 Completed Date: 1993-04-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: G280-4 Citation Subset: IM |
Affiliation:
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Center for Ulcer Research and Education, Veterans Affairs Medical Center, Los Angeles, California. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine / analogs & derivatives, pharmacology Brain / physiology* Gastric Acid / secretion Hyperemia / etiology* Injections, Intraventricular Male NG-Nitroarginine Methyl Ester Nitric Oxide / metabolism* Pyrrolidonecarboxylic Acid / analogs & derivatives Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects Stereoisomerism Stomach / blood supply* Thyrotropin-Releasing Hormone / analogs & derivatives*, pharmacology Vagus Nerve / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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DK-30110/DK/NIDDK NIH HHS; DK-41301/DK/NIDDK NIH HHS; MH-00663/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 24305-27-9/Thyrotropin-Releasing Hormone; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; 76820-40-1/L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide; 98-79-3/Pyrrolidonecarboxylic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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