Document Detail

Role of nitric oxide in gastric hyperemia induced by central vagal stimulation.
MedLine Citation:
PMID:  8447409     Owner:  NLM     Status:  MEDLINE    
The effects of N omega-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthesis, on the vagal cholinergic increase in gastric mucosal blood flow (GMBF) and acid secretion induced by intracisternal injection of the thyrotropin-releasing hormone (TRH) analogue, RX 77368, were studied. GMBF and acid secretion were measured simultaneously by the hydrogen gas clearance technique and titration of gastric perfusate in urethan-anesthetized rats. RX 77368 (30 ng) injected intracisternally stimulated gastric acid secretion and GMBF for 90 and 180 min respectively. GMBF was increased from basal 63 +/- 4 to 166 +/- 14 ml.min-1.100 g-1 at 60 min postinjection. L-NAME (3 mg/kg) injected intravenously 15 min before RX 77368 completely prevented the increase in GMBF induced by the TRH analogue, whereas the acid response was not modified. The effect of L-NAME was reversed by L-arginine but not by the stereoisomer D-arginine. These results show that the increase in GMBF, but not the stimulation of acid secretion, induced by central vagal activation is mediated through a product of L-arginine-NO pathway.
T Tanaka; P Guth; Y Taché
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  264     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-02     Completed Date:  1993-04-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G280-4     Citation Subset:  IM    
Center for Ulcer Research and Education, Veterans Affairs Medical Center, Los Angeles, California.
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MeSH Terms
Arginine / analogs & derivatives,  pharmacology
Brain / physiology*
Gastric Acid / secretion
Hyperemia / etiology*
Injections, Intraventricular
NG-Nitroarginine Methyl Ester
Nitric Oxide / metabolism*
Pyrrolidonecarboxylic Acid / analogs & derivatives
Rats, Sprague-Dawley
Regional Blood Flow / drug effects
Stomach / blood supply*
Thyrotropin-Releasing Hormone / analogs & derivatives*,  pharmacology
Vagus Nerve / physiology*
Grant Support
Reg. No./Substance:
10102-43-9/Nitric Oxide; 24305-27-9/Thyrotropin-Releasing Hormone; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; 76820-40-1/L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide; 98-79-3/Pyrrolidonecarboxylic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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