Document Detail


Role of nitric oxide in endotoxin-induced metabolic and vascular dysregulation of the canine diaphragm.
MedLine Citation:
PMID:  7633726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed the role of nitric oxide (NO) in the regulation of diaphragmatic O2 uptake (Vo2di) and phrenic vascular resistance during endotoxemia in anesthetized, mechanically ventilated dogs. Left diaphragmatic vasculature was isolated and briefly pump perfused with arterial blood at a normal flow rate, at a high rate (50% higher than normal), and at low rat (60 to 70% lower than normal). At each rate, Vo2di and phrenic perfusion pressure (Pphr) were measured. Escherichia coli endotoxin (100 mg) was infused intravenously over 90 min in several groups of animals, whereas normal saline was infused into the other. Endotoxin infusion increased Vo2di and reduced Pphr at a given flow rate. These parameters remained unchanged in the saline-infused animals. Infusion of NG-nitro-L-arginine methyl ester (LNAME 6 x 10(-4) M) into the phrenic artery of the endotoxin group reversed the decline in Pphr with no effect on Vo2di. LNAME infusion in the saline group increased Pphr at normal and high flow rates only. Single intravenous injections of LNAME increased arterial pressure and reduced cardiac output in endotoxemic animals, whereas only an increase in arterial pressure was observed in saline-infused animals. Serum arterial and phrenic venous NO concentrations measured in separate groups of animals increased significantly after endotoxin infusion, whereas saline infusion had no effect on these parameters. These results indicate that enhanced NO release plays a significant role in endotoxin-induced phrenic and systemic vasodilation. However, the increase in Vo2di in the endotoxin group does not seem to be mediated by NO release.
Authors:
S N Hussain
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  152     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-14     Completed Date:  1995-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  683-9     Citation Subset:  AIM; IM    
Affiliation:
Critical Care Division, Royal Victoria Hospital, Montreal, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arginine / administration & dosage,  analogs & derivatives,  pharmacology
Blood Pressure / drug effects
Cardiac Output / drug effects
Diaphragm / blood supply,  drug effects*,  metabolism
Dogs
Endotoxins / adverse effects*,  blood
Escherichia coli
Hypotension / metabolism,  physiopathology
Infusions, Intra-Arterial
Injections, Intravenous
NG-Nitroarginine Methyl Ester
Nitric Oxide / antagonists & inhibitors,  blood,  physiology*
Oxygen Consumption / drug effects
Regional Blood Flow
Shock, Septic / metabolism,  physiopathology
Vascular Resistance / drug effects
Vasodilation
Chemical
Reg. No./Substance:
0/Endotoxins; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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