Document Detail

Role of nitric oxide in adaptation to hypoxia and adaptive defense.
MedLine Citation:
PMID:  10805409     Owner:  NLM     Status:  MEDLINE    
Adaptation to hypoxia is beneficial in cardiovascular pathology related to NO shortage or overproduction. However, the question about the influence of adaptation to hypoxia on NO metabolism has remained open. The present work was aimed at the relationship between processes of NO production and storage during adaptation to hypoxia and the possible protective significance of these processes. Rats were adapted to intermittent hypobaric hypoxia in an altitude chamber. NO production was determined by plasma nitrite/nitrate level. Vascular NO stores were evaluated by relaxation of the isolated aorta to diethyldithiocarbamate. Experimental myocardial infarction was used as a model of NO overproduction; stroke-prone spontaneously hypertensive rats (SHR-SP) were used as a model of NO shortage. During adaptation to hypoxia, the plasma nitrite/nitrate level progressively increased and was correlated with the increase in NO stores. Adaptation to hypoxia prevented the excessive endothelium-dependent relaxation and hypotension characteristic for myocardial infarction. At the same time, the adaptation attenuated the increase in blood pressure and prevented the impairment of endothelium-dependent relaxation in SHR-SP. The data suggest that NO stores induced by adaptation to hypoxia can either bind excessive NO to protect the organism against NO overproduction or provide a NO reserve to be used in NO deficiency.
E B Manukhina; Mashina SYu; B V Smirin; N P Lyamina; V N Senchikhin; A F Vanin; Malyshev IYu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  49     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2000  
Date Detail:
Created Date:  2000-06-30     Completed Date:  2000-06-30     Revised Date:  2008-04-02    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  CZECH REPUBLIC    
Other Details:
Languages:  eng     Pagination:  89-97     Citation Subset:  IM; S    
Institute of General Pathology and Pathophysiology, Moscow, Russia.
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MeSH Terms
Adaptation, Physiological*
Anoxia / physiopathology*
Aorta / physiopathology
Blood Pressure
Endothelium, Vascular / physiopathology
Hypertension / physiopathology
Muscle Relaxation
Muscle, Smooth, Vascular / physiopathology
Myocardial Infarction / physiopathology
Nitrates / blood
Nitric Oxide / physiology*
Nitrites / blood
Rats, Inbred SHR
Rats, Wistar
Reg. No./Substance:
0/Nitrates; 0/Nitrites; 10102-43-9/Nitric Oxide

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