Document Detail

Role of nitric oxide and adenosine in the onset of vasodilation during dynamic forearm exercise.
MedLine Citation:
PMID:  22692759     Owner:  NLM     Status:  Publisher    
We tested the hypothesis that nitric oxide (NO) and adenosine contribute to the onset of vasodilation during dynamic forearm exercise. Twenty-two subjects performed rhythmic forearm exercise (20 % of maximum) during control and NO synthase (NOS) inhibition (N (G)-monomethyl-L: -arginine; L: -NMMA) trials. A subset of subjects performed a third trial of forearm exercise during combined inhibition of NOS and adenosine (aminophylline; n = 9). Additionally, a separate group of subjects (n = 7) performed rhythmic forearm exercise during control, inhibition of adenosine alone and combined inhibition of adenosine and NOS. Forearm vascular conductance (FVC; ml min(-1) · 100 mmHg(-1)) was calculated from blood flow and mean arterial pressure (mmHg). The onset of vasodilation was assessed by calculating the slope of the FVC response for every duty cycle between baseline and steady state, and the number of duty cycles (1-s contraction/2-s relaxation) to reach steady state. NOS inhibition blunted vasodilation at the onset of exercise (11.1 ± 0.8 vs. 8.5 ± 0.6 FVC units/duty cycle; P < 0.001 vs. control) and increased the time to reach steady state (25 ± 1 vs. 32 ± 1 duty cycles; P < 0.001 vs. control). Vasodilation was blunted further with combined inhibition of NOS and adenosine (7.5 ± 0.6 vs. 6.2 ± 0.8 FVC units/duty cycle; P < 0.05 vs. L: -NMMA alone), but not with aminophylline alone (16.0 ± 2.2 vs. 14.7 ± 2.0 FVC units/duty cycle; P = 0.67 vs. control). Our data indicate that NO and adenosine (in the absence of NO) contribute to the onset of vasodilation during dynamic forearm exercise.
Darren P Casey; Essa A Mohamed; Michael J Joyner
Related Documents :
12690939 - Improving understanding of exercise effects on in vitro t-lymphocyte function--the role...
18206729 - Effects of exercise on hematological parameters, circulating side population cells, and...
18388249 - Cytokine responses to acute and chronic exercise in multiple sclerosis.
9810649 - Respiratory burst of human polymorphonuclear leukocytes in response to the galactoside-...
22685479 - Evaluation of functional electrical stimulation to assist cycling in four adolescents w...
8897029 - Exercise-induced alterations in natural killer cell number and function.
23960689 - Effects of a preoperative individualized exercise program on selected recovery variable...
4046839 - Effects of exercise and physical fitness on the pituitary-thyroid axis and on prolactin...
6259099 - Exercise and the camp system in rat adipose tissue. i. lipid mobilization.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-13
Journal Detail:
Title:  European journal of applied physiology     Volume:  -     ISSN:  1439-6327     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Anesthesiology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Analysis of pre-treatment markers predictive of treatment benefit for the therapeutic cancer vaccine...
Next Document:  Immunohistochemical analysis of TGF-?1 and VEGF in gingival and periodontal tissues: A role of these...