| Role of nitric oxide (NO) in the regulation of coronary circulation. | |
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MedLine Citation:
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PMID: 9085349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitric oxide plays an important role in the control of basal coronary tone and mediation of reactive hyperaemic flow response following short-term coronary occlusion. The results presented in this report indicate that NO is involved in the modulation of coronary autoregulation in isolated rat hearts. Isolated rat heart exhibit autoregulation of coronary flow (CF) between 50 and 80 cm H2O of coronary perfusion pressure (CPP). Within this autoregulatory range NO release (measured as nitrite) varies from 1.7 +/- 0.3 to 2.2 +/- 0.7 nmol/min/g wt. Below the autoregulatory range it decreases slightly, while above this there is more than a twofold increase. Changes of NO release are accompanied by directly proportional changes of cGMP release. The release of hypoxanthine + xanthine shows a reciprocal relationship to CF values. The inhibition of NO synthesis showed a reciprocal relationship with CF values. Inhibition of NO synthesis by L-NAME (30 mumol/l) significantly reduces CF over the entire range of CPP changes (20-120 cm H2O), but much less at lower than at higher pressure values. Therefore, the autoregulatory range is significantly widened to CPP of 40-100 cm H2O. Theophylline (30 mumol/l) reduces CF by 15-25% throughout the entire range of CPP changes. Hence, the CPP-CF curve is shifted downwards without significant changes of the autoregulatory range. Theophylline-induced reduction of NO release is CPP-dependent: as greater as CPP lower. When L-NAME is coadministered with theophylline, CF is additionally reduced while widened autoregulatory range is shifted to the right. |
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Authors:
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M M Kostić; M R Petronijević; V L Jakovljević |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 45 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 1996 |
Date Detail:
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Created Date: 1997-06-06 Completed Date: 1997-06-06 Revised Date: 2008-04-02 |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: CZECH REPUBLIC |
Other Details:
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Languages: eng Pagination: 273-8 Citation Subset: IM |
Affiliation:
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Institute of Physiology, Faculty of Medicne, University of Kragujevac, Yugoslavia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation / physiology* Enzyme Inhibitors / pharmacology Homeostasis / physiology Lactates / metabolism Myocardium / metabolism* NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide / physiology* Nitrites / metabolism Perfusion Rats Rats, Wistar Theophylline / pharmacology Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Lactates; 0/Nitrites; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 58-55-9/Theophylline |
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