| Role of nitric oxide on GABA, glutamic acid, activities of GABA-T and GAD in rat brain cerebral cortex. | |
| | |
MedLine Citation:
|
PMID: 10434007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The results of the present study clearly shows that a correlation exists between nitric oxide (NO) and gamma-aminobutyric acid transaminase (GABAT-T) activity as well as gamma-aminobutyric acid (GABA), glutamic acid and the activity of glutamic acid decarboxylase (GAD). Supporting of this 10 min after the administration of L-Arginine (L-Arg) increased GABA concentration and diminished the activity of GABA-T. There was no change in GAD activity and glutamic acid level. Administration of convulsion inducing agent Picrotoxin (PCT) decreased the NO concentration in the brain and enhanced the activity of GABA-T, and the fact that the NOS inhibitor (N(G)-nitro-L-Arg methyl ester (L-NAME) diminished the activity of NOS and increased the activity of GABA-T provide another support for the involvement of NO on GABA-T activity. The present study clearly showed that high concentrations of NO in the brain suppresses the activity of GABA-T. |
| | |
Authors:
|
A R Jayakumar; R Sujatha; V Paul; C Asokan; S Govindasamy; R Jayakumar |
Related Documents
:
|
21978827 - A target analogue imprinted polymer for the recognition of antiplatelet active ingredie... 75177 - The requirement of specific antibody for the killing of e. coli by the alternate comple... 6131937 - Desmethylimipramine enhances the release of endogenous gaba and other neurotransmitter ... 6366787 - Aminomalonic acid: identification in escherichia coli and atherosclerotic plaque. 3008557 - Use of two different deoxyribonucleic acid probes to detect y chromosome deoxyribonucle... 3656217 - Effects of extracellular potassium on acid release and motility initiation in toxoplasm... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Brain research Volume: 837 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1999 Aug |
Date Detail:
|
Created Date: 1999-10-21 Completed Date: 1999-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 229-35 Citation Subset: IM |
Copyright Information:
|
Copyright 1999 Published by Elsevier Science B.V. |
Affiliation:
|
Bio-organic and Neurochemistry Laboratory, Central Leather Research Institute, Adyar, Chennai - 600 020, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
4-Aminobutyrate Transaminase
/
metabolism* Animals Arginine / pharmacology Cerebral Cortex / drug effects, metabolism* Glutamate Decarboxylase / metabolism* Glutamic Acid / metabolism* Male NG-Nitroarginine Methyl Ester / pharmacology* Nitric Oxide / physiology* Picrotoxin / pharmacology Rats Rats, Wistar gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
|
10102-43-9/Nitric Oxide; 124-87-8/Picrotoxin; 50903-99-6/NG-Nitroarginine Methyl Ester; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid; 74-79-3/Arginine; EC 2.6.1.19/4-Aminobutyrate Transaminase; EC 4.1.1.15/Glutamate Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Frequency-dependent changes in cerebral blood flow and evoked potentials during somatosensory stimul...
Next Document: Prolactin activates all three populations of hypothalamic neuroendocrine dopaminergic neurons in ova...