Document Detail

Role of nitrergic input in mechanically and chemically induced gastric relaxation in conscious dogs.
MedLine Citation:
PMID:  15215633     Owner:  NLM     Status:  MEDLINE    
Our aim was to study a role of nitrergic input in gastric relaxation in conscious dogs. Proximal gastric motor responses to mechanical distension and chemical stimulation (a lipid meal orally) were evaluated by electronic barostat. Effect of N(G)-monomethyl-L-arginine acetate (L-NMMA, 5 mg/kg) on these responses was studied. When mechanical stimulation was applied, we observed steep linear increases in intragastric pressure up to about 6 mmHg, then continued to increase gradually, and could be increased still further upon the addition of L-NMMA. Oral application of a lipid led to a prompt fall in intragastric pressure (gastric receptive relaxation; GRR). Lipid treatment also led to a considerable increase in gastric volume (means +/- S.D., 150.0 +/- 50.2 ml), this was followed by a plateau phase and a gradual return to baseline levels. Neither GRR nor the associated increase in gastric volume (167.6 +/- 53.0 ml) was sensitive to treatment with L-NMMA. Our conclusion is that nitrergic input is necessary for mechanically induced gastric relaxation, but not for either GRR or chemically-induced gastric relaxation in conscious dogs.
Masafumi Kikkawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi     Volume:  40     ISSN:  0916-8737     ISO Abbreviation:  J Smooth Muscle Res     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-06-24     Completed Date:  2004-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9211664     Medline TA:  J Smooth Muscle Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  53-64     Citation Subset:  IM    
Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Minami-ku, Japan.
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MeSH Terms
Enzyme Inhibitors / pharmacology
Gastric Emptying / drug effects,  physiology*
Muscle Relaxation / drug effects,  physiology*
Nitric Oxide / physiology*
Physical Stimulation
Stimulation, Chemical
Stomach / physiology*
omega-N-Methylarginine / pharmacology
Reg. No./Substance:
0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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