Document Detail

Role of neural pathways in renin response to intravascular volume expansion.
MedLine Citation:
PMID:  6990789     Owner:  NLM     Status:  MEDLINE    
This study was designed to evaluate the physiological importance of cardiopulmonary receptors with vagal afferents in controlling renin release during perturbations in blood volume. Intravascular volume of chloralose-anesthetized dogs was expanded by 7.5 ml/kg body wt, with an isotonic isoncotic solution containing 3% dextran for colloid. Volume expansion resulted in a 50% decline in renin secretion. However, volume expansion after bilateral cervical vagotomy, the proposed afferent limb of the reflex, also suppressed renin release. In another group of animals, the left kidney was surgically denervated and the right kidney extirpated, and again infusion suppressed resin release. In all groups, the infusion significantly suppressed renin release when compared to each dog's own control period, as well as when compared to the corresponding time controls. Our data indicate that the renin response to intravascular volume expansion was not mediated solely by the vagi or renal nerves. A combination of intrarenal factors may, however, have been responsible for the suppression of renin release observed. Our results do not support the hypothesis that the renin-angiotensin system is an efferent limb of the cardiopulmonary reflex during adjustments to alterations in blood volume.
S J Fisher; R L Malvin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  238     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-07-28     Completed Date:  1980-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H611-7     Citation Subset:  IM; S    
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MeSH Terms
Blood Volume*
Kidney / innervation,  secretion
Mechanoreceptors / physiology*
Reflex / physiology*
Renin / secretion*
Vagus Nerve / physiology*
Reg. No./Substance:

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