Document Detail


Role of nebulized amphotericin B in the management of allergic bronchopulmonary aspergillosis in cystic fibrosis: case report and review of literature.
MedLine Citation:
PMID:  24824366     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives: To review the data available in literature about nebulized amphotericin B (AMB) in the treatment of allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF) and to report our experience in the use of this drug, with a particular therapeutic scheme. Case Report: We used nebulized liposomal amphotericin B (L-AMB) in a patient affected by CF, complicated by ABPA. The previous combined treatment with oral steroids and azoles had no respiratory benefit and caused relevant side effects. Amphotericin B has always been well tolerated and permitted a slight steroid tapering. We also observed benefits in pulmonary function and laboratory tests. Conclusions: Few data are available in literature about the use of nebulized AMB in CF and there are no RCTs evaluating antifungals in CF-ABPA. In our opinion, the reported case suggests that nebulized L-AMB could represent a possible strategy in ABPA management in CF patients.
Authors:
Rosaria Casciaro; Aldo Naselli; Federico Cresta; Mirco Ros; Elio Castagnola; Laura Minicucci
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-14
Journal Detail:
Title:  Journal of chemotherapy (Florence, Italy)     Volume:  -     ISSN:  1973-9478     ISO Abbreviation:  J Chemother     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907348     Medline TA:  J Chemother     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1973947814Y0000000194     Citation Subset:  -    
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