| Role of nasopharyngeal colonization with and without bacteremia in the protection of infant rats against Haemophilus influenzae type b challenge. | |
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MedLine Citation:
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PMID: 3871734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nasopharyngeal colonization of infant rats with Haemophilus influenzae type b was investigated by two methods of intranasal inoculation. After traumatic instillation of the bacteria, 100% of the animals became colonized, compared with 75.5% of animals after atraumatic instillation. Among colonized rats, significantly more animals in the traumatic group developed bacteremia compared with those in the atraumatic group. Rats in the traumatic group had an onset of bacteremia at a mean of 2.6 days after inoculation compared with 7.3 days in the atraumatic group. The duration of colonization and bacteremia was the same in both groups. The majority of heavily colonized rats developed bacteremia compared with none of the lightly colonized rats. Thus, the development of bacteremia appeared to be related independently to both heavy colonization and traumatic instillation. Protection against intraperitoneal bacterial challenge with H. influenzae type b developed in rats that had been bacteremic; in the majority of animals, this correlated with the development of serum bactericidal activity. Protection and bactericidal activity were only rarely observed in nonbacteremic rats that had been either heavily or lightly colonized. The development of serum bactericidal activity was not related to either the duration or peak level of bacteremia. Thus, in this rat model, H. influenzae type b nasopharyngeal colonization without bacteremia did not appear to stimulate circulating antibodies that protected the animals against challenge. |
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Authors:
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J R Gilsdorf; P Ferrieri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Infection and immunity Volume: 47 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-04-18 Completed Date: 1985-04-18 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 648-53 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Bacterial / immunology Blood Bactericidal Activity Disease Models, Animal Haemophilus Infections / microbiology, prevention & control* Haemophilus influenzae / immunology Immunization Meningitis, Haemophilus / microbiology, prevention & control Nasopharynx / immunology Rats Sepsis |
| Grant Support | |
ID/Acronym/Agency:
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AI-07054/AI/NIAID NIH HHS; AI-13926/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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