Document Detail

Role of myelin-associated neuraminidase in the ganglioside metabolism of rat brain myelin.
MedLine Citation:
PMID:  1727447     Owner:  NLM     Status:  MEDLINE    
The role of myelin-associated neuraminidase in ganglioside metabolism was examined using rats of ages ranging from 17 to 97 days. The neuraminidase activity directed toward the ganglioside GM3 in the total myelin fraction was high during the period of active myelination and, thereafter, decreased rapidly to the adult level. The ganglioside composition became simpler during development with an increasing amount of GM1 and decreasing percentages of di- and polysialogangliosides. The decrease in the proportion of GD1a was most prominent, whereas relative amounts of GD1b and GT1b increased transiently before reducing to the adult levels. The heavy myelin subfraction contained higher percentages of di- and polysialo-species compared to the light myelin fraction at young and adult ages. The in vitro incubation of myelin of young rats under an optimal condition for neuraminidase action produced a profile of ganglioside changes similar to that observed in in vivo development. These results strongly suggest that myelin-associated neuraminidase may play a pivotal role in the developmental changes in the ganglioside composition of rat brain myelin.
M Saito; R K Yu
Related Documents :
7140857 - Age changes in the h1 group of histones from rat liver.
9392787 - Susceptibility of adult rats to lead-induced changes in nmda receptor complex function.
372297 - Age-related changes in aortic intima of rats.
6514137 - Vasopressin release from individually superfused neurohypophyses decreases in aged rats.
6524257 - Experimental endometriosis and fertility: compared effects of an antigonadotropin (dana...
16563857 - Significance and fate of septal fibrosis of the liver.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  58     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-01-22     Completed Date:  1992-01-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  83-7     Citation Subset:  IM    
Department of Biochemistry and Molecular Biophysics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aging / metabolism
Brain / metabolism*
Gangliosides / metabolism*
Myelin Sheath / enzymology,  metabolism*
Neuraminidase / physiology*
Grant Support
Reg. No./Substance:
0/Gangliosides; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Neuraminidase activities in oligodendroglial cells of the rat brain.
Next Document:  Characterization of the serpin, alpha 1-antichymotrypsin, in normal human cerebrospinal fluid.