Document Detail


Role of myelin-associated neuraminidase in the ganglioside metabolism of rat brain myelin.
MedLine Citation:
PMID:  1727447     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of myelin-associated neuraminidase in ganglioside metabolism was examined using rats of ages ranging from 17 to 97 days. The neuraminidase activity directed toward the ganglioside GM3 in the total myelin fraction was high during the period of active myelination and, thereafter, decreased rapidly to the adult level. The ganglioside composition became simpler during development with an increasing amount of GM1 and decreasing percentages of di- and polysialogangliosides. The decrease in the proportion of GD1a was most prominent, whereas relative amounts of GD1b and GT1b increased transiently before reducing to the adult levels. The heavy myelin subfraction contained higher percentages of di- and polysialo-species compared to the light myelin fraction at young and adult ages. The in vitro incubation of myelin of young rats under an optimal condition for neuraminidase action produced a profile of ganglioside changes similar to that observed in in vivo development. These results strongly suggest that myelin-associated neuraminidase may play a pivotal role in the developmental changes in the ganglioside composition of rat brain myelin.
Authors:
M Saito; R K Yu
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  58     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-01-22     Completed Date:  1992-01-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  83-7     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Biophysics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism
Animals
Brain / metabolism*
Female
Gangliosides / metabolism*
Hydrolysis
Myelin Sheath / enzymology,  metabolism*
Neuraminidase / physiology*
Rats
Grant Support
ID/Acronym/Agency:
NS-11853/NS/NINDS NIH HHS; NS-23102/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Gangliosides; EC 3.2.1.18/Neuraminidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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