| Role of modulation of vascular endothelial growth factor and tumor necrosis factor-alpha in gastric ulcer healing in diabetic rats. | |
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MedLine Citation:
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PMID: 20144589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to assess the effect of drugs that increase gastric vascular endothelial growth factor (VEGF) and suppress gastric tumor necrosis factor-alpha (TNF-alpha) in gastric ulcer healing in streptozotocin-induced diabetic rats. Sixty male albino rats were made diabetic by intraperitoneal (i.p.) streptozotocin injection and ten rats were injected i.p. by a single dose of saline. Six weeks following streptozotocin or saline injection, gastric ulcers were induced by serosal application of acetic acid. Three days after acetic acid application, rats were divided into: group I (non-diabetic control), group II (streptozotocin-injected), groups III-VII (streptozotocin-injected rats treated with insulin, insulin and pentoxifylline, insulin and simvastatin, pentoxifylline as well as simvastatin, respectively, for 7 days following acetic acid application. The use of insulin, combinations of insulin and pentoxifylline or simvastatin resulted in a significant decrease in gastric ulcer area, significant increase in epithelial regeneration assessed histologically, significant increase in gastric VEGF concentration, and gastric von Willebrand factor (vWF) as well as significant decrease in gastric TNF-alpha. A significant difference in gastric ulcer area as well as in gastric TNF-alpha, VEGF and vWF levels could be observed between rats that received combinations of insulin and pentoxifylline or simvastatin compared to rats that received either drug alone. Our results suggest the feasibility of a novel treatment strategy, namely pentoxifylline and simvastatin, for patients in whom impairment of ulcer healing constitutes a secondary complication of diabetes mellitus. |
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Authors:
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Azza M Baraka; Aida Guemei; Hala Abdel Gawad |
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Publication Detail:
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Type: Journal Article Date: 2010-02-06 |
Journal Detail:
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Title: Biochemical pharmacology Volume: 79 ISSN: 1873-2968 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-03-29 Completed Date: 2010-05-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 1634-9 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Pharmacology Dept, Alexandria University, Egypt. mnhbaraka@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acid Animals Anticholesteremic Agents Diabetes Mellitus, Experimental / complications*, drug therapy Free Radical Scavengers Insulin / pharmacology, therapeutic use Male Pentoxifylline / pharmacology, therapeutic use Rats Rats, Wistar Simvastatin / pharmacology, therapeutic use Stomach Ulcer / drug therapy* Streptozocin Treatment Outcome Tumor Necrosis Factor-alpha / analysis, drug effects* Vascular Endothelial Growth Factor A / analysis, drug effects* Wound Healing / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Free Radical Scavengers; 0/Tumor Necrosis Factor-alpha; 0/Vascular Endothelial Growth Factor A; 11061-68-0/Insulin; 18883-66-4/Streptozocin; 64-19-7/Acetic Acid; 6493-05-6/Pentoxifylline; 79902-63-9/Simvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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