| Role of mitochondrial variation in maternally inherited diabetes and deafness syndrome. | |
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MedLine Citation:
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PMID: 18950542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternally inherited diabetes and deafness syndrome is caused by the mitochondrial deoxyribonucleic acid mutation 3243 A>G (where A = adenine and G = guanine). The degree of heteroplasmy of the mitochondrial deoxyribonucleic acid may correlate with the rate of progression of the hearing loss. This has important implications for counselling patients with this pathology. Cochlear implantation is a successful method of rehabilitation for patients with hearing loss as part of this syndrome. |
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Authors:
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T Howes; C Madden; S Dasgupta; S Saeed; V Das |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of laryngology and otology Volume: 122 ISSN: 1748-5460 ISO Abbreviation: J Laryngol Otol Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-27 Completed Date: 2009-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706896 Medline TA: J Laryngol Otol Country: England |
Other Details:
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Languages: eng Pagination: 1249-52 Citation Subset: AIM; IM |
Affiliation:
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University Department of Audiological Medicine, Manchester Royal Infirmary, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cochlear Implantation / methods* DNA, Mitochondrial / genetics* Diabetes Mellitus / genetics*, surgery Female Hearing Loss, Sensorineural / genetics*, surgery Humans Mitochondrial Diseases / genetics, surgery* Pedigree Phenotype Point Mutation / genetics* Syndrome Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/DNA, Mitochondrial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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