Document Detail

Role of the midline glia and neurons in the formation of the axon commissures in the central nervous system of the Drosophila embryo.
MedLine Citation:
PMID:  1789544     Owner:  NLM     Status:  MEDLINE    
A row of midline precursor cells separates the two lateral neurogenic regions that give rise to most of the Drosophila CNS. From these midline precursors arises a discrete set of special glia and neurons. The growth cones of many CNS neurons initially head straight towards the midline and change their behavior after traversing it, leading to the hypothesis that these midline cells play a key role in the formation of the axon commissures. We have used a variety of cellular and molecular genetic techniques to elucidate the cells and interactions, including specific cell migrations, that are important for the normal formation of the two major commissures in each segment. This cellular analysis has led to a model that proposes a series of sequential cell interactions controlling the three stages in commissure development: (1) formation of the posterior commissure, (2) formation of the anterior commissure, and (3) separation of the two commissures. An initial genetic test of this model has used a number of mutations that, by either eliminating or altering the differentiation of various midline cells, perturb the development of the axon commissures in a predictable manner.
C Klämbt; C S Goodman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  633     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-24     Completed Date:  1992-03-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  142-59     Citation Subset:  IM    
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720.
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MeSH Terms
Axons / physiology*
Cell Line
Cell Movement
Central Nervous System / cytology,  embryology*
Drosophila / embryology*,  genetics
Models, Neurological
Neuroglia / physiology*
Neurons / physiology*
Stem Cells / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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