Document Detail


Role of microsomal ethanol-oxidizing system in regulation of linoleoyl-CoA desaturase activity after long-term ethanol administration.
MedLine Citation:
PMID:  3358827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic ethanol administration resulted in a decrease of rat liver linoleoyl-CoA desaturase activity and an activation of MEOS. This was accompanied by an increase in the activity of the NADPH-dependent system and the oxidation rate of NADH-oxidase, which suggests transfer of electrons from NADH to cytochrome P-450. The decreased linoleoyl-CoA desaturase activity may be due to insufficient supply of electrons, because of possible diversion to MEOS.
Authors:
V U Buko; L I Sushko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  23     ISSN:  0735-0414     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:  1988  
Date Detail:
Created Date:  1988-06-09     Completed Date:  1988-06-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  69-71     Citation Subset:  IM    
Affiliation:
Institute of Biochemistry, Byelorussian SSR Academy of Sciences, Grodno.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cytochrome Reductases / metabolism
Cytochrome-B(5) Reductase
Ethanol / metabolism*
Fatty Acid Desaturases / metabolism*
Linoleoyl-CoA Desaturase
Liver / enzymology*
Male
Microsomes, Liver / enzymology,  physiology*
Multienzyme Complexes / metabolism
NADH, NADPH Oxidoreductases / metabolism
Oxidation-Reduction
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Multienzyme Complexes; 64-17-5/Ethanol; EC 1.14.19.-/Fatty Acid Desaturases; EC 1.14.19.3/Linoleoyl-CoA Desaturase; EC 1.6.-/NADH oxidase; EC 1.6.-/NADH, NADPH Oxidoreductases; EC 1.6.2.-/Cytochrome Reductases; EC 1.6.2.2/Cytochrome-B(5) Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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