| Role of microRNA pathway in mental retardation. | |
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MedLine Citation:
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PMID: 17982588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Deficits in cognitive functions lead to mental retardation (MR). Understanding the genetic basis of inherited MR has provided insights into the pathogenesis of MR. Fragile X syndrome is one of the most common forms of inherited MR, caused by the loss of functional Fragile X Mental Retardation Protein (FMRP). MicroRNAs (miRNAs) are endogenous, single-stranded RNAs between 18 and 25 nucleotides in length, which have been implicated in diversified biological pathways. Recent studies have linked the miRNA pathway to fragile X syndrome. Here we review the role of the miRNA pathway in fragile X syndrome and discuss its implication in MR in general. |
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Authors:
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Abrar Qurashi; Shuang Chang; Jin Peng |
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Publication Detail:
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Type: Journal Article; Review Date: 2007-11-02 |
Journal Detail:
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Title: TheScientificWorldJournal Volume: 7 ISSN: 1537-744X ISO Abbreviation: ScientificWorldJournal Publication Date: 2007 |
Date Detail:
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Created Date: 2007-11-05 Completed Date: 2007-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101131163 Medline TA: ScientificWorldJournal Country: England |
Other Details:
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Languages: eng Pagination: 146-54 Citation Subset: IM |
Affiliation:
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Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biogenesis Fragile X Mental Retardation Protein / genetics Humans Mental Retardation / genetics* MicroRNAs / genetics* Neurons / metabolism |
| Chemical | |
Reg. No./Substance:
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0/MicroRNAs; 139135-51-6/Fragile X Mental Retardation Protein |
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