Document Detail


Role of microRNAs in cardiac preconditioning.
MedLine Citation:
PMID:  20980922     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preconditioning (PC) of the heart by sublethal ischemia, mild heat shock, or hypoxia has evolved as a powerful experimental tool to discover novel signaling mechanisms in cardioprotection. The ultimate goal is to determine novel therapeutic targets for potential application in humans to protect the heart against ischemia-related injuries. In recent years, there has been a tremendous interest in understanding the role of small noncoding RNAs, microRNAs (miRs), in cardiovascular diseases. miRs have been recognized as regulators of gene expression by destabilization and translational inhibition of target messenger RNAs. Studies have shown that several miRs, including miR-1, miR-133, miR-21, miR-126, miR-320, miR-92a, and miR-199a, are regulated after preconditioning and play an active role in protecting the heart against ischemia/reperfusion injury. These miRs also drive the synthesis of important cardioprotective proteins including heat shock protein (HSP)-70, endothelial nitric oxide synthase, inducible nitric oxide synthase, HSP-20, Sirt1, and hypoxia-inducible factor 1a. We believe that identification and targeted delivery of miR(s) in the heart could have an immense therapeutic potential in reducing myocardial infarction in patients suffering from heart disease.
Authors:
Fadi N Salloum; Chang Yin; Rakesh C Kukreja
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  56     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-04-21     Completed Date:  2012-02-14     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  581-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Genetic Therapy / methods,  trends
Humans
Ischemic Preconditioning, Myocardial / methods*,  trends
MicroRNAs / physiology*,  therapeutic use
Myocardial Reperfusion Injury / genetics,  prevention & control*
Neovascularization, Pathologic / genetics,  prevention & control
Grant Support
ID/Acronym/Agency:
HL51045/HL/NHLBI NIH HHS; HL59469/HL/NHLBI NIH HHS; HL79424/HL/NHLBI NIH HHS; R01 HL079424/HL/NHLBI NIH HHS; R01 HL093685/HL/NHLBI NIH HHS; R37 HL051045/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/MicroRNAs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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