Document Detail


Role of metallothionein in differentiation of leukemia cells.
MedLine Citation:
PMID:  20127519     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Metallothioneins (MTs), a group of small, cystein-rich proteins, possess various functions, including metal detoxification and homeostasis. We here report new findings on the participation of MT in cellular differentiation processes. MT isogene transcription was significantly increased in phorbol-12-myristate-13-acetate (PMA) incubated leukemic DAMI cells, which supports its role in cellular differentiation. To further address this possibility, we constructed one stable MT-2A overexpressing DAMI cell line. Increase of cell size, intracellular granulation and megakaryocytic specific antigen expression such as CD41 and CD42, and arresting cell proliferation have validated the role of MT in differentiation in this cell line.
Authors:
Pegah Maghdooni Bagheri; Iris Govaerts; Marc De Ley
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Publication Detail:
Type:  Journal Article     Date:  2010-02-03
Journal Detail:
Title:  Molecular biology reports     Volume:  38     ISSN:  1573-4978     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3017-22     Citation Subset:  IM    
Affiliation:
Laboratory for Biochemistry, Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200G, mailbox 2413, 3001, Leuven (Heverlee), Belgium.
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