Document Detail


Role of metallothionein in differentiation of leukemia cells.
MedLine Citation:
PMID:  20127519     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Metallothioneins (MTs), a group of small, cystein-rich proteins, possess various functions, including metal detoxification and homeostasis. We here report new findings on the participation of MT in cellular differentiation processes. MT isogene transcription was significantly increased in phorbol-12-myristate-13-acetate (PMA) incubated leukemic DAMI cells, which supports its role in cellular differentiation. To further address this possibility, we constructed one stable MT-2A overexpressing DAMI cell line. Increase of cell size, intracellular granulation and megakaryocytic specific antigen expression such as CD41 and CD42, and arresting cell proliferation have validated the role of MT in differentiation in this cell line.
Authors:
Pegah Maghdooni Bagheri; Iris Govaerts; Marc De Ley
Related Documents :
6150939 - Endocrine cells in extrahepatic bile duct carcinoma.
3163939 - Modulation of 6-thioguanine activity by guanine in human promyelocytic leukemia hl-60 c...
6802509 - Induction of differentiation of human promyelocytic leukemia (hl-60) cells by teleocidi...
18841249 - Polyelectrolyte multilayer films of controlled stiffness modulate myoblast cells differ...
6228579 - Human helper t cell factor(s). iii. characterization of b cell differentiation factor i...
15572029 - Gdnf-induced leukemia inhibitory factor can mediate differentiation via the mek/erk pat...
17291719 - Role of caspases in cd95l- and trail-induced non-apoptotic signalling in pancreatic tum...
24882759 - Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth fact...
1397079 - Heat shock-induced redistribution of a 160-kda nuclear matrix protein.
Publication Detail:
Type:  Journal Article     Date:  2010-02-03
Journal Detail:
Title:  Molecular biology reports     Volume:  38     ISSN:  1573-4978     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3017-22     Citation Subset:  IM    
Affiliation:
Laboratory for Biochemistry, Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200G, mailbox 2413, 3001, Leuven (Heverlee), Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The cardioprotective effect of fluvastatin on ischemic injury via down-regulation of toll-like recep...
Next Document:  Complement factor H Y402H gene polymorphism and coronary heart disease susceptibility: a meta-analys...