| Role of metallothionein in differentiation of leukemia cells. | |
| | |
MedLine Citation:
|
PMID: 20127519 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Metallothioneins (MTs), a group of small, cystein-rich proteins, possess various functions, including metal detoxification and homeostasis. We here report new findings on the participation of MT in cellular differentiation processes. MT isogene transcription was significantly increased in phorbol-12-myristate-13-acetate (PMA) incubated leukemic DAMI cells, which supports its role in cellular differentiation. To further address this possibility, we constructed one stable MT-2A overexpressing DAMI cell line. Increase of cell size, intracellular granulation and megakaryocytic specific antigen expression such as CD41 and CD42, and arresting cell proliferation have validated the role of MT in differentiation in this cell line. |
| | |
Authors:
|
Pegah Maghdooni Bagheri; Iris Govaerts; Marc De Ley |
Related Documents
:
|
6150939 - Endocrine cells in extrahepatic bile duct carcinoma. 3163939 - Modulation of 6-thioguanine activity by guanine in human promyelocytic leukemia hl-60 c... 6802509 - Induction of differentiation of human promyelocytic leukemia (hl-60) cells by teleocidi... 18841249 - Polyelectrolyte multilayer films of controlled stiffness modulate myoblast cells differ... 6228579 - Human helper t cell factor(s). iii. characterization of b cell differentiation factor i... 15572029 - Gdnf-induced leukemia inhibitory factor can mediate differentiation via the mek/erk pat... 17291719 - Role of caspases in cd95l- and trail-induced non-apoptotic signalling in pancreatic tum... 1397079 - Heat shock-induced redistribution of a 160-kda nuclear matrix protein. 1473269 - Normal and ha-ras-1 oncogene transformed buffalo rat liver (brl) cells show differentia... |
Publication Detail:
|
Type: Journal Article Date: 2010-02-03 |
Journal Detail:
|
Title: Molecular biology reports Volume: 38 ISSN: 1573-4978 ISO Abbreviation: Mol. Biol. Rep. Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-05-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0403234 Medline TA: Mol Biol Rep Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 3017-22 Citation Subset: IM |
Affiliation:
|
Laboratory for Biochemistry, Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200G, mailbox 2413, 3001, Leuven (Heverlee), Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The cardioprotective effect of fluvastatin on ischemic injury via down-regulation of toll-like recep...
Next Document: Complement factor H Y402H gene polymorphism and coronary heart disease susceptibility: a meta-analys...