Document Detail

Role of metallothionein in Helicobacter pylori-positive gastric mucosa with or without early gastric cancer and the effect on its expression after eradication therapy.
MedLine Citation:
PMID:  17725597     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: Metallothionein (MT) has a proven relationship with various kinds of cancer and reduces tissue damage. Helicobacter pylori (H. pylori) infection is associated with the alteration of gastric epithelial cell cycle events, a condition implicated in the initiation and development of gastric cancer. This study investigates the role of MT in H. pylori-induced gastritis with or without early gastric cancer (ECG) and evaluates the effect on MT expression after eradication therapy. METHODS: Gastric biopsy samples were immunohistochemically examined for MT expression in 36 H. pylori-negative patients without ECG and 98 positive patients with or without ECG. Real time polymerase chain reaction was performed in 14 antral biopsy samples with or without H. pylori. The severity of gastritis was also evaluated according to the updated Sydney System. In 31 successfully eradicated patients, the above assessment was repeated for two consecutive years. RESULTS: MT expression was higher in H. pylori-negative patients than in positive patients (P < 0.01). Moreover, in the corpus it was higher in H. pylori-positive patients without ECG compared to those with ECG (P < 0.05). The MT labeling index had a negative correlation with the severity of gastritis (P < 0.01). A positive correlation was shown between the MT labeling index and apoptosis: proliferation ratio (r = 0.41, P < 0.01). The MT labeling index in H. pylori-positive patients was gradually recovered after eradication (P < 0.05). CONCLUSION: The decrease of MT expression cannot prevent tissue damage in H. pylori-positive gastric mucosa and leads to more severe gastritis. This phenomenon may be attributed to gastric carcinogenesis. H. pylori eradication increases MT expression and may reduce the risk of ECG.
Toshifumi Mitani; Daisuke Shirasaka; Nobuo Aoyama; Ikuya Miki; Yoshinori Morita; Nobunao Ikehara; Yuko Matsumoto; Tatsuya Okuno; Masanori Toyoda; Hideyuki Miyachi; Shiei Yoshida; Naoko Chayahara; Junko Hori; Takao Tamura; Takeshi Azuma; Masato Kasuga
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Publication Detail:
Type:  Journal Article     Date:  2007-08-27
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  23     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-13     Completed Date:  2008-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  e334-9     Citation Subset:  IM    
Departments of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Gastric Mucosa / microbiology*
Helicobacter Infections / complications,  drug therapy*,  metabolism*
Helicobacter pylori*
Metallothionein / biosynthesis,  physiology*
Stomach Neoplasms / complications*,  physiopathology,  prevention & control
Reg. No./Substance:
0/Anti-Bacterial Agents; 9038-94-2/Metallothionein

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