| Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome. | |
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MedLine Citation:
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PMID: 18202092 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile X syndrome, the most common inherited form of mental retardation and autism. Since a reduction of mGluR5 signalling can reverse fragile X phenotypes, these studies provide a compelling rationale for the use of mGluR5 antagonists for the treatment of fragile X and related disorders. |
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Authors:
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Gül Dölen; Mark F Bear |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2008-01-17 |
Journal Detail:
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Title: The Journal of physiology Volume: 586 ISSN: 1469-7793 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-17 Completed Date: 2008-04-23 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 1503-8 Citation Subset: IM |
Affiliation:
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Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism*, pathology* Fragile X Syndrome / metabolism*, pathology* Mice Mice, Knockout Neurons / metabolism*, pathology* Receptors, Metabotropic Glutamate / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Metabotropic Glutamate; 0/metabotropic glutamate receptor 5 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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