Document Detail


Role of membrane traffic in the generation of epithelial cell asymmetry.
MedLine Citation:
PMID:  23196841     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epithelial cells have an apical-basolateral axis of polarity, which is required for epithelial functions including barrier formation, vectorial ion transport and sensory perception. Here we review what is known about the sorting signals, machineries and pathways that maintain this asymmetry, and how polarity proteins interface with membrane-trafficking pathways to generate membrane domains de novo. It is becoming apparent that membrane traffic does not simply reinforce polarity, but is critical for the generation of cortical epithelial cell asymmetry.
Authors:
Gerard Apodaca; Luciana I Gallo; David M Bryant
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Nature cell biology     Volume:  14     ISSN:  1476-4679     ISO Abbreviation:  Nat. Cell Biol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-01-28     Revised Date:  2013-09-17    
Medline Journal Info:
Nlm Unique ID:  100890575     Medline TA:  Nat Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1235-43     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. gla6@pitt.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Membrane / metabolism*
Cell Polarity / genetics,  physiology
Epithelial Cells / cytology*,  metabolism*
Humans
Mice
Models, Biological
Protein Transport / genetics,  physiology*
Signal Transduction / genetics,  physiology
Grant Support
ID/Acronym/Agency:
K99 CA163535/CA/NCI NIH HHS; K99CA163535/CA/NCI NIH HHS; R01DK077777/DK/NIDDK NIH HHS; R37DK54425/DK/NIDDK NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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