| Role of the medial preoptic area in thermal preference of rats. | |
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MedLine Citation:
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PMID: 11883151 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was conducted to find out whether the medial preoptic area (mPOA) plays a role in the selection of ambient temperature by rats. Adult male Wistar rats were kept in an environmental chamber having three interconnected compartments, maintained at three different temperatures (18 degrees, 24 degrees and 30 degrees C) in which the animals could move freely from one compartment to the other. Normal rats preferred to stay at the chamber maintained at 24 degrees C for most of the time, during day and night. The temperature preference shifted to 30 degrees C after the mPOA of these rats had been lesioned by local administration of 5 micrograms of N-methyl D-aspartic acid (NMDA) in 0.2 microliter distilled water. The results of the study suggest that the mPOA acts as a fine tuning center for homeostatic regulation of thermal balance, including selection of appropriate thermal environment. It is proposed that after the mPOA lesion, the animal cannot assess properly the energy status of the body and thereby prefers a higher ambient temperature. |
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Authors:
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B Ray; H Mallick; V M Kumar |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Indian journal of physiology and pharmacology Volume: 45 ISSN: 0019-5499 ISO Abbreviation: Indian J. Physiol. Pharmacol. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2002-03-08 Completed Date: 2002-08-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374707 Medline TA: Indian J Physiol Pharmacol Country: India |
Other Details:
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Languages: eng Pagination: 445-50 Citation Subset: IM |
Affiliation:
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Department of Physiology, All India Institute of Medical Sciences, New Delhi-110 029. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation Energy Metabolism Male Preoptic Area / physiology* Rats Rats, Wistar Temperature |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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