| Role of the medial amygdala in mediating responses to aversive stimuli leading to hypertension. | |
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MedLine Citation:
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PMID: 20528979 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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1. The amygdala is a part of the limbic system that is associated with mediating the emotional and hormonal response to stress and although studies have focused on the central amygdala, there is increasing evidence that the medial amygdala is a major region activated by stressful stimuli. 2. Neuroanatomical studies in rats have shown greater activation in the medial amygdala following aversive stresses compared with other brain regions, including the central amygdala. Inhibition of the medial, but not the central, amygdala attenuates the development of hypertension in spontaneously hypertensive rats. 3. Schlager (BPH/2J) mice have a neurogenic form of hypertension that is most evident during the night when the mice are most active and is closely correlated with the level of activation of neurons in the medial, but not the central, amygdala. Pressor responses to aversive stimuli, such as restraint and cage-switch stress, are much greater in BPH/2J hypertensive than BPN/3J normotensive mice, but appetitive arousal produces normal increases in blood pressure. The degree of activation in the medial amygdala in BPH/2J hypertensive mice during aversive stress closely correlates with the increased blood pressure. 4. Thus, the inappropriate activation of the medial amygdala evoked by specific fear or aversive stimuli may be key to the neurogenic hypertension. |
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Authors:
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Pamela J Davern; Geoffrey A Head |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 38 ISSN: 1440-1681 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: Australia |
Other Details:
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Languages: eng Pagination: 136-43 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Clinical and Experimental Pharmacology and Physiology © 2011 Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Institute Department of Pharmacology, Monash University, Melbourne, Victoria, Australia. |
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