Document Detail


Role of mast cells in gynecological neoplasms.
MedLine Citation:
PMID:  23276962     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mast cells are of paramount importance in allergic reactions, pathogen immune responses during infection, and angiogenesis, as well as innate and adaptive immune regulation. Beyond all these roles, mast cells are now increasingly being recognized as modulators of tumor biology and fate. Notwithstanding mounting evidence of mast cell accumulation in tumors, their exact role in tumorigenesis and tumor progression is still incompletely understood. Although some evidence suggests that mast cells can promote tumorigenesis, there are some clinical sets as well as experimental tumor models in which mast cells seem to have functions that favor the host. This article focuses on the significant roles of mast cells in the mechanism, early diagnosis, differential diagnosis and evaluation of prognosis of gynecological neoplasms, with particular emphasis on the capacity of these cells to stimulate tumor growth by promoting angiogenesis, and highlight recent findings on the integral roles of mast cells in gynecological neoplasm growth, such as cervical and breast cancer. Information to be presented suggests that mast cells may become useful tools for future anticancer therapies.
Authors:
Lingling Jiang; Ying Hua; Qi Shen; Shendi Ding; Wenxiao Jiang; Wenwen Zhang; Xueqiong Zhu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  773-81     Citation Subset:  IM    
Affiliation:
No. 109 Xueyuan Xi Road, Department of Obstetrics and Gynecology, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, 325027, China.
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MeSH Terms
Descriptor/Qualifier:
Cell Transformation, Neoplastic / pathology
Chymases / metabolism
Female
Genital Neoplasms, Female / immunology*,  pathology
Gestational Trophoblastic Disease / immunology
Humans
Leiomyoma / diagnosis
Mast Cells / immunology*,  physiology
Pregnancy
Uterine Cervical Neoplasms / etiology
Uterine Neoplasms / diagnosis
Vulvar Neoplasms / immunology
Chemical
Reg. No./Substance:
EC 3.4.21.39/CMA1 protein, human; EC 3.4.21.39/Chymases

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