Document Detail


Role of magnesium in hypertension.
MedLine Citation:
PMID:  16762312     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Magnesium affects blood pressure by modulating vascular tone and reactivity. It acts as a calcium channel antagonist, it stimulates production of vasodilator prostacyclins and nitric oxide and it alters vascular responses to vasoactive agonists. Magnesium deficiency has been implicated in the pathogenesis of hypertension with epidemiological and experimental studies demonstrating an inverse correlation between blood pressure and serum magnesium levels. Magnesium also influences glucose and insulin homeostasis, and hypomagnesemia is associated with metabolic syndrome. Although most epidemiological and experimental studies support a role for low magnesium in the pathophysiology of hypertension, data from clinical studies have been less convincing. Furthermore, the therapeutic value of magnesium in the management of hypertension is unclear. The present review addresses the role of magnesium in the regulation of vascular function and blood pressure and discusses the implications of magnesium deficiency in experimental and clinical hypertension, in metabolic syndrome and in pre-eclampsia.
Authors:
Bruno Sontia; Rhian M Touyz
Publication Detail:
Type:  Journal Article; Review     Date:  2006-05-24
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  458     ISSN:  0003-9861     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-06     Completed Date:  2007-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  33-9     Citation Subset:  IM    
Affiliation:
Kidney Research Centre, Ottawa Health Research Institute, University of Ottawa, Ontario, Canada K1H 8M5.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Hypertension / physiopathology*
Magnesium / physiology*
Chemical
Reg. No./Substance:
7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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